TY  - JOUR
AU  - Radak, Đorđe J.
AU  - Đukić, Nenad
AU  - Tanasković, Slobodan
AU  - Obradović, Milan M.
AU  - Cenić-Milošević, Desanka
AU  - Isenović, Esma R.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1522
AB  - Endovascular surgery represents a minimally invasive procedure for the treatment of occlusive and aneurysmal arterial disease. However, it is followed by inflammatory response, with a rise in specific inflammatory biomarkers, such as C-reactive protein, serum amyloid A and fibrinogen. Shear stress during balloon inflation and vascular injury represents triggering events for the inflammatory process, stimulating the production of proinflammatory molecules and activation of circulating monocytes. The current literature indicates that stent implantation induces more prominent inflammatory reaction. Additionally, it has been shown that muscular arteries of femoropopliteal segment react to a greater extent to stent implantation, compared with elastic carotid or iliac arteries. The endovascular treatment of thoracic and abdominal aortic aneurysm is frequently followed with post-implantation inflammatory syndrome. Most recent findings point out that stent graft material plays a significant role in the inflammatory response, representing a challenge for clinicians. Future studies should consider the pathophysiology of the inflammatory response associated with endovascular procedures as well as predictors and risk factors including preventive strategies and therapeutic algorithms. Although the potential role of anti-inflammatory drugs after endovascular procedures has been observed, it needs to be validated in upcoming trials. The Neutrophil Lymphocyte Ratio, platelet count, Platelet-to-Lymphocyte Ratio and other biomarkers should be considered in future trials to assess the inflammatory response after endovascular procedures. Inflammatory markers may also become therapeutic targets.
T2  - Current Vascular Pharmacology
T1  - Should We be Concerned About the Inflammatory Response to Endovascular Procedures?
VL  - 15
IS  - 3
SP  - 230
EP  - 237
DO  - 10.2174/1570161115666170105121900
ER  - 

@article{
author = "Radak, Đorđe J. and Đukić, Nenad and Tanasković, Slobodan and Obradović, Milan M. and Cenić-Milošević, Desanka and Isenović, Esma R.",
year = "2017",
abstract = "Endovascular surgery represents a minimally invasive procedure for the treatment of occlusive and aneurysmal arterial disease. However, it is followed by inflammatory response, with a rise in specific inflammatory biomarkers, such as C-reactive protein, serum amyloid A and fibrinogen. Shear stress during balloon inflation and vascular injury represents triggering events for the inflammatory process, stimulating the production of proinflammatory molecules and activation of circulating monocytes. The current literature indicates that stent implantation induces more prominent inflammatory reaction. Additionally, it has been shown that muscular arteries of femoropopliteal segment react to a greater extent to stent implantation, compared with elastic carotid or iliac arteries. The endovascular treatment of thoracic and abdominal aortic aneurysm is frequently followed with post-implantation inflammatory syndrome. Most recent findings point out that stent graft material plays a significant role in the inflammatory response, representing a challenge for clinicians. Future studies should consider the pathophysiology of the inflammatory response associated with endovascular procedures as well as predictors and risk factors including preventive strategies and therapeutic algorithms. Although the potential role of anti-inflammatory drugs after endovascular procedures has been observed, it needs to be validated in upcoming trials. The Neutrophil Lymphocyte Ratio, platelet count, Platelet-to-Lymphocyte Ratio and other biomarkers should be considered in future trials to assess the inflammatory response after endovascular procedures. Inflammatory markers may also become therapeutic targets.",
journal = "Current Vascular Pharmacology",
title = "Should We be Concerned About the Inflammatory Response to Endovascular Procedures?",
volume = "15",
number = "3",
pages = "230-237",
doi = "10.2174/1570161115666170105121900"
}

Radak, Đ. J., Đukić, N., Tanasković, S., Obradović, M. M., Cenić-Milošević, D.,& Isenović, E. R.. (2017). Should We be Concerned About the Inflammatory Response to Endovascular Procedures?. in Current Vascular Pharmacology, 15(3), 230-237.
https://doi.org/10.2174/1570161115666170105121900

Radak ĐJ, Đukić N, Tanasković S, Obradović MM, Cenić-Milošević D, Isenović ER. Should We be Concerned About the Inflammatory Response to Endovascular Procedures?. in Current Vascular Pharmacology. 2017;15(3):230-237.
doi:10.2174/1570161115666170105121900 .

Radak, Đorđe J., Đukić, Nenad, Tanasković, Slobodan, Obradović, Milan M., Cenić-Milošević, Desanka, Isenović, Esma R., "Should We be Concerned About the Inflammatory Response to Endovascular Procedures?" in Current Vascular Pharmacology, 15, no. 3 (2017):230-237,
https://doi.org/10.2174/1570161115666170105121900 . .

TY  - JOUR
AU  - Radak, Đorđe J.
AU  - Tanasković, Slobodan
AU  - Katsiki, Niki
AU  - Isenović, Esma R.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1005
AB  - An inverse association between diabetes mellitus (DM) and abdominal aortic aneurysm (AAA) risk have been reported. Apart from a lower AAA prevalence among patients with vs without DM, there are data showing that DM may exert a protective role on aneurysmal growth in patients with small AAAs, thus decreasing the risk of rupture. As atherosclerosis has almost the same risk factors as aneurysms, the decreased AAA prevalence in patients with DM may indicate that atherosclerosis is an associated feature and not a cause of the aneurysms. Alternatively, DM may be associated with factors that influence AAA formation. In this narrative review, we discuss the inverse association between DM and AAA. We also comment on underlying cellular and genetic pathophysiological mechanisms of DM, AAA and atherosclerosis. The effects of drugs, commonly prescribed in DM patients, on AAA development and growth are also considered.
T2  - Current Vascular Pharmacology
T1  - Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?
VL  - 14
IS  - 2
SP  - 196
EP  - 200
DO  - 10.2174/1570161113666150529125127
ER  - 

@article{
author = "Radak, Đorđe J. and Tanasković, Slobodan and Katsiki, Niki and Isenović, Esma R.",
year = "2016",
abstract = "An inverse association between diabetes mellitus (DM) and abdominal aortic aneurysm (AAA) risk have been reported. Apart from a lower AAA prevalence among patients with vs without DM, there are data showing that DM may exert a protective role on aneurysmal growth in patients with small AAAs, thus decreasing the risk of rupture. As atherosclerosis has almost the same risk factors as aneurysms, the decreased AAA prevalence in patients with DM may indicate that atherosclerosis is an associated feature and not a cause of the aneurysms. Alternatively, DM may be associated with factors that influence AAA formation. In this narrative review, we discuss the inverse association between DM and AAA. We also comment on underlying cellular and genetic pathophysiological mechanisms of DM, AAA and atherosclerosis. The effects of drugs, commonly prescribed in DM patients, on AAA development and growth are also considered.",
journal = "Current Vascular Pharmacology",
title = "Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?",
volume = "14",
number = "2",
pages = "196-200",
doi = "10.2174/1570161113666150529125127"
}

Radak, Đ. J., Tanasković, S., Katsiki, N.,& Isenović, E. R.. (2016). Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?. in Current Vascular Pharmacology, 14(2), 196-200.
https://doi.org/10.2174/1570161113666150529125127

Radak ĐJ, Tanasković S, Katsiki N, Isenović ER. Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?. in Current Vascular Pharmacology. 2016;14(2):196-200.
doi:10.2174/1570161113666150529125127 .

Radak, Đorđe J., Tanasković, Slobodan, Katsiki, Niki, Isenović, Esma R., "Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?" in Current Vascular Pharmacology, 14, no. 2 (2016):196-200,
https://doi.org/10.2174/1570161113666150529125127 . .

TY  - JOUR
AU  - Radak, Đorđe J.
AU  - Sotirovic, Vuk
AU  - Tanasković, Slobodan
AU  - Isenović, Esma R.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5436
AB  - Before the routine use of computed tomography (CT) angiography, decisions for carotid artery treatment were mostly based on ultrasound findings and conventional angiography. Implementation and increasing use of CT angiography provided better visualization of the carotid and vertebrobasilar arteries system leading to an unexpected more frequent detection of unruptured intracranial aneurysms (UIAs). Concomitant presence of intracranial aneurysms in patients with severe carotid stenosis is a potential cause of significant mortality and morbidity. Due to the possible higher risk of aneurysm rupture after carotid procedures and ischemic events after aneurysm repair, the simultaneous presence of both lesions creates several therapeutic dilemmas. We review the prevalence of UIAs in patients with carotid occlusive disease and management difficulties and the current treatment strategies for handling the concomitant presence of these life-threatening diseases.
T2  - Angiology
T1  - Intracranial Aneurysms in Patients With Carotid Disease: Not So Rare As We Think
VL  - 65
IS  - 1
SP  - 12
EP  - 16
DO  - 10.1177/0003319712468938
ER  - 

@article{
author = "Radak, Đorđe J. and Sotirovic, Vuk and Tanasković, Slobodan and Isenović, Esma R.",
year = "2014",
abstract = "Before the routine use of computed tomography (CT) angiography, decisions for carotid artery treatment were mostly based on ultrasound findings and conventional angiography. Implementation and increasing use of CT angiography provided better visualization of the carotid and vertebrobasilar arteries system leading to an unexpected more frequent detection of unruptured intracranial aneurysms (UIAs). Concomitant presence of intracranial aneurysms in patients with severe carotid stenosis is a potential cause of significant mortality and morbidity. Due to the possible higher risk of aneurysm rupture after carotid procedures and ischemic events after aneurysm repair, the simultaneous presence of both lesions creates several therapeutic dilemmas. We review the prevalence of UIAs in patients with carotid occlusive disease and management difficulties and the current treatment strategies for handling the concomitant presence of these life-threatening diseases.",
journal = "Angiology",
title = "Intracranial Aneurysms in Patients With Carotid Disease: Not So Rare As We Think",
volume = "65",
number = "1",
pages = "12-16",
doi = "10.1177/0003319712468938"
}

Radak, Đ. J., Sotirovic, V., Tanasković, S.,& Isenović, E. R.. (2014). Intracranial Aneurysms in Patients With Carotid Disease: Not So Rare As We Think. in Angiology, 65(1), 12-16.
https://doi.org/10.1177/0003319712468938

Radak ĐJ, Sotirovic V, Tanasković S, Isenović ER. Intracranial Aneurysms in Patients With Carotid Disease: Not So Rare As We Think. in Angiology. 2014;65(1):12-16.
doi:10.1177/0003319712468938 .

Radak, Đorđe J., Sotirovic, Vuk, Tanasković, Slobodan, Isenović, Esma R., "Intracranial Aneurysms in Patients With Carotid Disease: Not So Rare As We Think" in Angiology, 65, no. 1 (2014):12-16,
https://doi.org/10.1177/0003319712468938 . .

TY  - JOUR
AU  - Radak, Đorđe J.
AU  - Davidović, Lazar
AU  - Tanasković, Slobodan
AU  - Banzić, Igor
AU  - Matić, Predrag
AU  - Babić, Srđan
AU  - Kostić, Dušan
AU  - Isenović, Esma R.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/86
AB  - BACKGROUND: To present outcomes following an operative approach of extracranial carotid artery aneurysm (ECAAs) based on anatomic types and associated kinks. METHODS: This study represents retrospective analysis of anatomic type based approach to operative repair of 84 patients with ECAA from 1994 to 2011, 28 (33.3%) with associated kinking. Patients were followed for neurological ischemic events, hematoma, cranial nerve injury, myocardial infarction, neurological, and overall mortality. The results are presented as early, within 30 days after the surgery, and long term during the follow-up. RESULTS: In the early postoperative period, there were no strokes or mortalities, cranial nerve injury rate was 2.4% while 1 patient had myocardial infarction (1.2%). During the follow-up, 4 patients (4.8%) had stroke, out of which 2 patients died (2.3%), while overall mortality was 4.6%. The average 5-year survival rate was 96 +/- 3%. CONCLUSION: Excellent outcomes can be obtained with surgical repair of ECAA, which should be tailored to the anatomic types and presence of kinks. (C) 2014 Elsevier Inc. All rights reserved.
T2  - American Journal of Surgery
T1  - A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks
VL  - 208
IS  - 2
SP  - 235
EP  - 242
DO  - 10.1016/j.amjsurg.2013.10.025
ER  - 

@article{
author = "Radak, Đorđe J. and Davidović, Lazar and Tanasković, Slobodan and Banzić, Igor and Matić, Predrag and Babić, Srđan and Kostić, Dušan and Isenović, Esma R.",
year = "2014",
abstract = "BACKGROUND: To present outcomes following an operative approach of extracranial carotid artery aneurysm (ECAAs) based on anatomic types and associated kinks. METHODS: This study represents retrospective analysis of anatomic type based approach to operative repair of 84 patients with ECAA from 1994 to 2011, 28 (33.3%) with associated kinking. Patients were followed for neurological ischemic events, hematoma, cranial nerve injury, myocardial infarction, neurological, and overall mortality. The results are presented as early, within 30 days after the surgery, and long term during the follow-up. RESULTS: In the early postoperative period, there were no strokes or mortalities, cranial nerve injury rate was 2.4% while 1 patient had myocardial infarction (1.2%). During the follow-up, 4 patients (4.8%) had stroke, out of which 2 patients died (2.3%), while overall mortality was 4.6%. The average 5-year survival rate was 96 +/- 3%. CONCLUSION: Excellent outcomes can be obtained with surgical repair of ECAA, which should be tailored to the anatomic types and presence of kinks. (C) 2014 Elsevier Inc. All rights reserved.",
journal = "American Journal of Surgery",
title = "A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks",
volume = "208",
number = "2",
pages = "235-242",
doi = "10.1016/j.amjsurg.2013.10.025"
}

Radak, Đ. J., Davidović, L., Tanasković, S., Banzić, I., Matić, P., Babić, S., Kostić, D.,& Isenović, E. R.. (2014). A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks. in American Journal of Surgery, 208(2), 235-242.
https://doi.org/10.1016/j.amjsurg.2013.10.025

Radak ĐJ, Davidović L, Tanasković S, Banzić I, Matić P, Babić S, Kostić D, Isenović ER. A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks. in American Journal of Surgery. 2014;208(2):235-242.
doi:10.1016/j.amjsurg.2013.10.025 .

Radak, Đorđe J., Davidović, Lazar, Tanasković, Slobodan, Banzić, Igor, Matić, Predrag, Babić, Srđan, Kostić, Dušan, Isenović, Esma R., "A tailored approach to operative repair of extracranial carotid aneurysms based on anatomic types and kinks" in American Journal of Surgery, 208, no. 2 (2014):235-242,
https://doi.org/10.1016/j.amjsurg.2013.10.025 . .

TY  - JOUR
AU  - Tanasković, Slobodan
AU  - Isenović, Esma R.
AU  - Radak, Đorđe J.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4520
AB  - The role of inflammation is well established in the pathogenesis of atherosclerosis and an increased level of circulating inflammatory markers may predict the future risk of atherosclerosis progression and plaque rupture. C-reactive protein (CRP) identification by hypersensitive methods (high-sensitivity CRP [hsCRP]) has become a clinical and laboratory inflammation marker. Carotid endarterectomy (CEA) is a well-established procedure for carotid stenosis treatment which can reduce stroke rate. Internal carotid artery (ICA) restenosis reduction may be prevented by the anti-inflammatory effect of statins. This review considers the recent findings on the presence of hsCRP and C3 complement concentration and inflammatory plaque composition as well as their effects on ICA restenosis rate, following eversion CEA with emphasis on human studies.
T2  - Angiology
T1  - Inflammation as a Marker for the Prediction of Internal Carotid Artery Restenosis Following Eversion Endarterectomy-Evidence From Clinical Studies
VL  - 62
IS  - 7
SP  - 535
EP  - 542
DO  - 10.1177/0003319710398010
ER  - 

@article{
author = "Tanasković, Slobodan and Isenović, Esma R. and Radak, Đorđe J.",
year = "2011",
abstract = "The role of inflammation is well established in the pathogenesis of atherosclerosis and an increased level of circulating inflammatory markers may predict the future risk of atherosclerosis progression and plaque rupture. C-reactive protein (CRP) identification by hypersensitive methods (high-sensitivity CRP [hsCRP]) has become a clinical and laboratory inflammation marker. Carotid endarterectomy (CEA) is a well-established procedure for carotid stenosis treatment which can reduce stroke rate. Internal carotid artery (ICA) restenosis reduction may be prevented by the anti-inflammatory effect of statins. This review considers the recent findings on the presence of hsCRP and C3 complement concentration and inflammatory plaque composition as well as their effects on ICA restenosis rate, following eversion CEA with emphasis on human studies.",
journal = "Angiology",
title = "Inflammation as a Marker for the Prediction of Internal Carotid Artery Restenosis Following Eversion Endarterectomy-Evidence From Clinical Studies",
volume = "62",
number = "7",
pages = "535-542",
doi = "10.1177/0003319710398010"
}

Tanasković, S., Isenović, E. R.,& Radak, Đ. J.. (2011). Inflammation as a Marker for the Prediction of Internal Carotid Artery Restenosis Following Eversion Endarterectomy-Evidence From Clinical Studies. in Angiology, 62(7), 535-542.
https://doi.org/10.1177/0003319710398010

Tanasković S, Isenović ER, Radak ĐJ. Inflammation as a Marker for the Prediction of Internal Carotid Artery Restenosis Following Eversion Endarterectomy-Evidence From Clinical Studies. in Angiology. 2011;62(7):535-542.
doi:10.1177/0003319710398010 .

Tanasković, Slobodan, Isenović, Esma R., Radak, Đorđe J., "Inflammation as a Marker for the Prediction of Internal Carotid Artery Restenosis Following Eversion Endarterectomy-Evidence From Clinical Studies" in Angiology, 62, no. 7 (2011):535-542,
https://doi.org/10.1177/0003319710398010 . .