@article{
author = "Milašin, Jelena and Dedović, Nasta and Pujić, Natalija and Vranić, Vesna and Mićić, S. and Dimitrijević, Bogomir B. and Diklić, V.",
year = "1992",
abstract = "DNK, izolovana iz 32 tumora bešike, analizirana je na prisustvo tačkastih mutacija H-ras gena za koji se zna da učestvuje u razvitku različitih malignih tumora čoveka. Primenom tehnike hibridizacije oligonuklotidnim probama na in vitro umnoženu tumorsku DNK, tačkaste mutacije na 12. i 13. kodonu H-ras gena detektovane su u 7 od 32 tumorska uzorka (22%). Ovako niska učestalost mutacija H-ras gena upućuje na zaključak da njihova aktivacija nije dominantni genetski događaj u razvitku tumora bešike, bar ne u većem delu te tumorske populacije., The DNA from thirty-two bladder cancers was screened for the presence of H-ras gene mutations, known to be involved in the pathogenesis of various human malignancies. Using the technique of oligonucleotide hybridization on previously in vitro amplified tumor DNA, H-ras mutations at codon 12 and 13 were detected in 7 out of 32 tumor specimens (22%). This low incidence of mutated ras genes suggests that their activation does not represent the crucial event in bladder tumor development, at least in the major part of tumor population.",
journal = "Archivum urologicum",
title = "Mutacije ras-gena u tumorima bešike, Ras gene mutations in bladder tumors",
volume = "14",
number = "35/36",
pages = "35-40",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9512"
}