@conference{
author = "Adžić, Miroslav and Đorđević, Ana D. and Đorđević, Jelena and Elaković, Ivana and Simić, Iva and Mitić, Miloš and Rackov, Gorjana and Matić, Gordana and Radojčić, Marija",
year = "2010",
abstract = "Alterations in the antioxidative defense parameters upon chronic stress are considered
critical for pathophysiology of stress related psychiatric disorders and their status in
blood serves as biomarker for effects of pharmacological treatments. We investigated
the modulation of erythrocyte antioxidant enzymes (AOEs): superoxide dismutase
(SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR)
protein expression and activity in Wistar male rats subjected to chronic psychosocial
isolation and/or treated with fluoxetine. Chronically isolated animals exhibited
decreased levels of plasma corticoserone (CORT). AOEs status was not altered either
by chronic social isolation or by fluoxetine. The only exception was GLR, whose level
and activity were both markedly reduced by fluoxetine. Our study indicates that
fluoxetine treatment of chronically isolated male Wistar rats, leads to significant
reduction in the level and activity of GLR in the erythrocytes.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2010 : 10th international conference on fundamental and applied aspects of physical chemistry",
title = "Fluoxetine decreases glutathione reductase in erythrocytes of chronically isolated wistar rats",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9306"
}