@conference{
author = "Orlovska, Iryna and Zmejkoski, Danica and Khirunenko, L. and Kozyrovska, N.",
year = "2017",
abstract = "Biofilm-forming multi-drug resistant pathogens may account for 10% of all hospital acquired infections and can occur in burns, post-surgical wounds, pressure injuries and diabetic foot wounds. Hydrogels – natural polymers or composite materials – represent both a bandage and a matrix for therapeutics in a wound healing. Novel composite based on bacterial cellulose and synthetic analog of lignin - DHP (dehydrogenate polymer) has been designed with the aim to suppress pathogenic agents in incurable wounds. The FT-IR spectra of the BC/DHP membrane established an appearance of characteristic for DHP absorption bands in the composite in the 1600–1510 cm−1 spectral range. A clear position of these bands in BC/DHP showed that DHP had been incorporated into the BC polymeric matrix. In addition, disappearance of the bands at the 3630–3650 cm−1 spectral range assigned to the cellulose free OH vibration, strengthening the bands assigned to intermolecular interactions and an appearance of a new band at 3293 cm−1 could serve as a proof of the interaction of BC molecules and DHP. Micrographs obtained from a scanning electron microscopy proved the dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number in the cellulose membrane. The antimicrobial activity of composites BC/DHP were tested the in vitro experiments, using Pseudomonas aeruginosa (УМВ-100) (MTT-test) and showed that BC/DHP inhibited P. aeruginosa. BC/DHP composite will be promising hydrogel for a healing of infected incurable wounds.",
journal = "Integrative Biology & Medicine : Program and Abstracts",
title = "A composite of bacterial cellulose and lignin for a healing of incurable wounds",
pages = "53-53",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13008"
}