Temperature/pH dual responsive OPGMA based copolymeric hydrogels prepared by gamma radiation: an optimisation study
Само за регистроване кориснике
2016
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The purpose of this study was to attain oligo(propylene glycol) methacrylate (OPGMA) based hydrogels for different biomedical applications. Since the volume phase transition temperature (VPTT) of poly(oligo(propylene glycol) methacrylate) (POPGMA) homopolymer was below room temperature, it was necessary to tune the thermoresponsiveness and the VPTT to higher temperatures; radical copolymerisation of OPGMA with more hydrophilic and/or pH responsive monomers was used to adjust these values. A series of copolymeric hydrogels with different ratios of OPGMA, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) was synthesised by gamma radiation. The swelling properties were preliminarily investigated over a wide pH (2.2-9.0) and temperature (4-80 degrees C) ranges. Additional characterization of their structure and properties was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The presented res...ults revealed temperature/pH dual responsive P(OPGMA/IA) and P(OPGMA/HEMA/IA) copolymers with large diversity in swelling properties, as a result of the addition of OPGMA thermoresponsive units with a lower critical solution temperature (LCST) and IA pH responsive units. It was demonstrated that VPTT can be significantly shifted to higher (e. g. body) temperatures at higher pH values (pH = 4) by increasing the IA content in the hydrogel composition. Due to the possibility of making dual responsive copolymers in the manner explained in this paper, OPGMA based hydrogels show potential for different biomedical applications.
Кључне речи:
Radiation synthesis / Smart hydrogel / Temperature/pH sensitivity / OPGMA / HEMA / IAИзвор:
Journal of Polymer Research, 2016, 23, 4Издавач:
- Springer
Финансирање / пројекти:
- Хемијско и структурно дизајнирање наноматеријала за примену у медицини и инжењерству ткива (RS-MESTD-Basic Research (BR or ON)-172026)
- Функционални, функционализовани и усавршени нано материјали (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45005)
DOI: 10.1007/s10965-016-0975-8
ISSN: 1022-9760; 1572-8935
WoS: 000373163400001
Scopus: 2-s2.0-84961620591
Институција/група
VinčaTY - JOUR AU - Rogić Miladinović, Zorana AU - Mićić, Maja M. AU - Suljovrujić, Edin H. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/989 AB - The purpose of this study was to attain oligo(propylene glycol) methacrylate (OPGMA) based hydrogels for different biomedical applications. Since the volume phase transition temperature (VPTT) of poly(oligo(propylene glycol) methacrylate) (POPGMA) homopolymer was below room temperature, it was necessary to tune the thermoresponsiveness and the VPTT to higher temperatures; radical copolymerisation of OPGMA with more hydrophilic and/or pH responsive monomers was used to adjust these values. A series of copolymeric hydrogels with different ratios of OPGMA, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) was synthesised by gamma radiation. The swelling properties were preliminarily investigated over a wide pH (2.2-9.0) and temperature (4-80 degrees C) ranges. Additional characterization of their structure and properties was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The presented results revealed temperature/pH dual responsive P(OPGMA/IA) and P(OPGMA/HEMA/IA) copolymers with large diversity in swelling properties, as a result of the addition of OPGMA thermoresponsive units with a lower critical solution temperature (LCST) and IA pH responsive units. It was demonstrated that VPTT can be significantly shifted to higher (e. g. body) temperatures at higher pH values (pH = 4) by increasing the IA content in the hydrogel composition. Due to the possibility of making dual responsive copolymers in the manner explained in this paper, OPGMA based hydrogels show potential for different biomedical applications. PB - Springer T2 - Journal of Polymer Research T1 - Temperature/pH dual responsive OPGMA based copolymeric hydrogels prepared by gamma radiation: an optimisation study VL - 23 IS - 4 DO - 10.1007/s10965-016-0975-8 ER -
@article{ author = "Rogić Miladinović, Zorana and Mićić, Maja M. and Suljovrujić, Edin H.", year = "2016", abstract = "The purpose of this study was to attain oligo(propylene glycol) methacrylate (OPGMA) based hydrogels for different biomedical applications. Since the volume phase transition temperature (VPTT) of poly(oligo(propylene glycol) methacrylate) (POPGMA) homopolymer was below room temperature, it was necessary to tune the thermoresponsiveness and the VPTT to higher temperatures; radical copolymerisation of OPGMA with more hydrophilic and/or pH responsive monomers was used to adjust these values. A series of copolymeric hydrogels with different ratios of OPGMA, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) was synthesised by gamma radiation. The swelling properties were preliminarily investigated over a wide pH (2.2-9.0) and temperature (4-80 degrees C) ranges. Additional characterization of their structure and properties was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The presented results revealed temperature/pH dual responsive P(OPGMA/IA) and P(OPGMA/HEMA/IA) copolymers with large diversity in swelling properties, as a result of the addition of OPGMA thermoresponsive units with a lower critical solution temperature (LCST) and IA pH responsive units. It was demonstrated that VPTT can be significantly shifted to higher (e. g. body) temperatures at higher pH values (pH = 4) by increasing the IA content in the hydrogel composition. Due to the possibility of making dual responsive copolymers in the manner explained in this paper, OPGMA based hydrogels show potential for different biomedical applications.", publisher = "Springer", journal = "Journal of Polymer Research", title = "Temperature/pH dual responsive OPGMA based copolymeric hydrogels prepared by gamma radiation: an optimisation study", volume = "23", number = "4", doi = "10.1007/s10965-016-0975-8" }
Rogić Miladinović, Z., Mićić, M. M.,& Suljovrujić, E. H.. (2016). Temperature/pH dual responsive OPGMA based copolymeric hydrogels prepared by gamma radiation: an optimisation study. in Journal of Polymer Research Springer., 23(4). https://doi.org/10.1007/s10965-016-0975-8
Rogić Miladinović Z, Mićić MM, Suljovrujić EH. Temperature/pH dual responsive OPGMA based copolymeric hydrogels prepared by gamma radiation: an optimisation study. in Journal of Polymer Research. 2016;23(4). doi:10.1007/s10965-016-0975-8 .
Rogić Miladinović, Zorana, Mićić, Maja M., Suljovrujić, Edin H., "Temperature/pH dual responsive OPGMA based copolymeric hydrogels prepared by gamma radiation: an optimisation study" in Journal of Polymer Research, 23, no. 4 (2016), https://doi.org/10.1007/s10965-016-0975-8 . .