The association of genetic variants IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510 with multiple sclerosis onset and severity in patients from Serbia
Само за регистроване кориснике
2020
Аутори
Stefanović, MilanŽivotić, Ivan
Stojković, Ljiljana S.
Dinčić, Evica
Stanković, Aleksandra
Živković, Maja
Чланак у часопису (Објављена верзија)
,
© 2020 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт
An algorithm Probabilistic Identification of Causal SNPs, identified 434 causal variants for multiple sclerosis (MS) including IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510. Analysis of individual and combined effects of these variants in the Serbian population identified that Il2RA rs2104286 G allele carriers had a lower risk for developing MS (gender adjusted OR = 0.63, p = .003). With regard to the IFI30 rs11554159 recessive genetic model, among HLA-DRB1*15:01 positive patients, the AA homozygote had a significantly higher MSSS compared to the G allele carriers (p = .003). This study confirms role of IL2RA rs2104286 in MS and suggest the role of IFI30 rs11554159 in disease severity, which needs validation.
Кључне речи:
Multiple sclerosis / Genetic variants / IL2RA / IFI30 / IKZF3 / Disease severityИзвор:
Journal of Neuroimmunology, 2020, 347, 577346-Финансирање / пројекти:
- Ministry of Education, Science and Technological Development of Republic of Serbia
DOI: 10.1016/j.jneuroim.2020.577346
ISSN: 0165-5728
PubMed: 32738499
WoS: 000567782100016
Scopus: 2-s2.0-85088976555
Институција/група
VinčaTY - JOUR AU - Stefanović, Milan AU - Životić, Ivan AU - Stojković, Ljiljana S. AU - Dinčić, Evica AU - Stanković, Aleksandra AU - Živković, Maja PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8885 AB - An algorithm Probabilistic Identification of Causal SNPs, identified 434 causal variants for multiple sclerosis (MS) including IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510. Analysis of individual and combined effects of these variants in the Serbian population identified that Il2RA rs2104286 G allele carriers had a lower risk for developing MS (gender adjusted OR = 0.63, p = .003). With regard to the IFI30 rs11554159 recessive genetic model, among HLA-DRB1*15:01 positive patients, the AA homozygote had a significantly higher MSSS compared to the G allele carriers (p = .003). This study confirms role of IL2RA rs2104286 in MS and suggest the role of IFI30 rs11554159 in disease severity, which needs validation. T2 - Journal of Neuroimmunology T1 - The association of genetic variants IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510 with multiple sclerosis onset and severity in patients from Serbia VL - 347 SP - 577346 DO - 10.1016/j.jneuroim.2020.577346 ER -
@article{ author = "Stefanović, Milan and Životić, Ivan and Stojković, Ljiljana S. and Dinčić, Evica and Stanković, Aleksandra and Živković, Maja", year = "2020", abstract = "An algorithm Probabilistic Identification of Causal SNPs, identified 434 causal variants for multiple sclerosis (MS) including IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510. Analysis of individual and combined effects of these variants in the Serbian population identified that Il2RA rs2104286 G allele carriers had a lower risk for developing MS (gender adjusted OR = 0.63, p = .003). With regard to the IFI30 rs11554159 recessive genetic model, among HLA-DRB1*15:01 positive patients, the AA homozygote had a significantly higher MSSS compared to the G allele carriers (p = .003). This study confirms role of IL2RA rs2104286 in MS and suggest the role of IFI30 rs11554159 in disease severity, which needs validation.", journal = "Journal of Neuroimmunology", title = "The association of genetic variants IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510 with multiple sclerosis onset and severity in patients from Serbia", volume = "347", pages = "577346", doi = "10.1016/j.jneuroim.2020.577346" }
Stefanović, M., Životić, I., Stojković, L. S., Dinčić, E., Stanković, A.,& Živković, M.. (2020). The association of genetic variants IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510 with multiple sclerosis onset and severity in patients from Serbia. in Journal of Neuroimmunology, 347, 577346. https://doi.org/10.1016/j.jneuroim.2020.577346
Stefanović M, Životić I, Stojković LS, Dinčić E, Stanković A, Živković M. The association of genetic variants IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510 with multiple sclerosis onset and severity in patients from Serbia. in Journal of Neuroimmunology. 2020;347:577346. doi:10.1016/j.jneuroim.2020.577346 .
Stefanović, Milan, Životić, Ivan, Stojković, Ljiljana S., Dinčić, Evica, Stanković, Aleksandra, Živković, Maja, "The association of genetic variants IL2RA rs2104286, IFI30 rs11554159 and IKZF3 rs12946510 with multiple sclerosis onset and severity in patients from Serbia" in Journal of Neuroimmunology, 347 (2020):577346, https://doi.org/10.1016/j.jneuroim.2020.577346 . .