Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females
Само за регистроване кориснике
2019
Аутори
Gluvić, ZoranSudar-Milovanović, Emina
Samardžić, Vladimir S.
Obradović, Milan M.
Jevremović, Danimir P.
Radenković, Saša P.
Isenović, Esma R.
Чланак у часопису (Објављена верзија)
,
© 2019 Elsevier Ltd
Метаподаци
Приказ свих података о документуАпстракт
Primary hypothyroidism can affect lipid metabolism, cardiovascular (CV) function, and overall patients’ quality of life (QoL). Decrease in serum nitric oxide (NO) levels could promote the atherosclerosis acceleration in hypothyroid patients. Our hypothesis is that serum NO level is altered in hypothyroidism; more specifically, we hypothesize that the early vascular changes that can be observed in hypothyroidism could be due to these alterations and that serum NO levels are associated with lipid levels in female patients diagnosed with subclinical hypothyroidism (SCH) or clinical hypothyroidism (CH). Furthermore, since serum NO level is an early marker of atherosclerosis and related CV disorders, which are commonly present and follow hypothyreosis and greatly contribute to overall QoL, we further hypothesized that NO level would correlate with Thyroid Symptom Questionnaire (TSQ) and General Health Questionnaire 12 (GHQ12) scores in hypothyroid patients. A collaterally of our hypothesis ...was that levothyroxine (LT4) treatment would affect serum NO levels as well as TSQ and GHQ12 scores. Therefore, we have analyzed lipid profile, the level of NO and QoL scores in female patients diagnosed with SCH and CH in order to determine the correlation between NO and generic and thyroid disease symptoms in treatment naïve SCH and CH patients and after LT4 treatment and laboratory euthyroidism achievement. As a consequence of our hypothesis is that measurement of serum NO level in SCH and CH patients may be an innovative way to improve LT4 treatment efficacy. This assumption could have a practical significance for future investigations regarding the management of hypothyroidism treatment protocols in current guidelines. © 2019 Elsevier Ltd
Кључне речи:
Hypothyroidism / Nitric oxide / Levothyroxine / Quality of lifeИзвор:
Medical Hypotheses, 2019, 131, 109299-Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.1016/j.mehy.2019.109299
ISSN: 0306-9877; 1532-2777
PubMed: 31443778
WoS: 000484646200003
Scopus: 2-s2.0-85068377510
Колекције
Институција/група
VinčaTY - JOUR AU - Gluvić, Zoran AU - Sudar-Milovanović, Emina AU - Samardžić, Vladimir S. AU - Obradović, Milan M. AU - Jevremović, Danimir P. AU - Radenković, Saša P. AU - Isenović, Esma R. PY - 2019 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8369 AB - Primary hypothyroidism can affect lipid metabolism, cardiovascular (CV) function, and overall patients’ quality of life (QoL). Decrease in serum nitric oxide (NO) levels could promote the atherosclerosis acceleration in hypothyroid patients. Our hypothesis is that serum NO level is altered in hypothyroidism; more specifically, we hypothesize that the early vascular changes that can be observed in hypothyroidism could be due to these alterations and that serum NO levels are associated with lipid levels in female patients diagnosed with subclinical hypothyroidism (SCH) or clinical hypothyroidism (CH). Furthermore, since serum NO level is an early marker of atherosclerosis and related CV disorders, which are commonly present and follow hypothyreosis and greatly contribute to overall QoL, we further hypothesized that NO level would correlate with Thyroid Symptom Questionnaire (TSQ) and General Health Questionnaire 12 (GHQ12) scores in hypothyroid patients. A collaterally of our hypothesis was that levothyroxine (LT4) treatment would affect serum NO levels as well as TSQ and GHQ12 scores. Therefore, we have analyzed lipid profile, the level of NO and QoL scores in female patients diagnosed with SCH and CH in order to determine the correlation between NO and generic and thyroid disease symptoms in treatment naïve SCH and CH patients and after LT4 treatment and laboratory euthyroidism achievement. As a consequence of our hypothesis is that measurement of serum NO level in SCH and CH patients may be an innovative way to improve LT4 treatment efficacy. This assumption could have a practical significance for future investigations regarding the management of hypothyroidism treatment protocols in current guidelines. © 2019 Elsevier Ltd T2 - Medical Hypotheses T1 - Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females VL - 131 SP - 109299 DO - 10.1016/j.mehy.2019.109299 ER -
@article{ author = "Gluvić, Zoran and Sudar-Milovanović, Emina and Samardžić, Vladimir S. and Obradović, Milan M. and Jevremović, Danimir P. and Radenković, Saša P. and Isenović, Esma R.", year = "2019", abstract = "Primary hypothyroidism can affect lipid metabolism, cardiovascular (CV) function, and overall patients’ quality of life (QoL). Decrease in serum nitric oxide (NO) levels could promote the atherosclerosis acceleration in hypothyroid patients. Our hypothesis is that serum NO level is altered in hypothyroidism; more specifically, we hypothesize that the early vascular changes that can be observed in hypothyroidism could be due to these alterations and that serum NO levels are associated with lipid levels in female patients diagnosed with subclinical hypothyroidism (SCH) or clinical hypothyroidism (CH). Furthermore, since serum NO level is an early marker of atherosclerosis and related CV disorders, which are commonly present and follow hypothyreosis and greatly contribute to overall QoL, we further hypothesized that NO level would correlate with Thyroid Symptom Questionnaire (TSQ) and General Health Questionnaire 12 (GHQ12) scores in hypothyroid patients. A collaterally of our hypothesis was that levothyroxine (LT4) treatment would affect serum NO levels as well as TSQ and GHQ12 scores. Therefore, we have analyzed lipid profile, the level of NO and QoL scores in female patients diagnosed with SCH and CH in order to determine the correlation between NO and generic and thyroid disease symptoms in treatment naïve SCH and CH patients and after LT4 treatment and laboratory euthyroidism achievement. As a consequence of our hypothesis is that measurement of serum NO level in SCH and CH patients may be an innovative way to improve LT4 treatment efficacy. This assumption could have a practical significance for future investigations regarding the management of hypothyroidism treatment protocols in current guidelines. © 2019 Elsevier Ltd", journal = "Medical Hypotheses", title = "Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females", volume = "131", pages = "109299", doi = "10.1016/j.mehy.2019.109299" }
Gluvić, Z., Sudar-Milovanović, E., Samardžić, V. S., Obradović, M. M., Jevremović, D. P., Radenković, S. P.,& Isenović, E. R.. (2019). Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females. in Medical Hypotheses, 131, 109299. https://doi.org/10.1016/j.mehy.2019.109299
Gluvić Z, Sudar-Milovanović E, Samardžić VS, Obradović MM, Jevremović DP, Radenković SP, Isenović ER. Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females. in Medical Hypotheses. 2019;131:109299. doi:10.1016/j.mehy.2019.109299 .
Gluvić, Zoran, Sudar-Milovanović, Emina, Samardžić, Vladimir S., Obradović, Milan M., Jevremović, Danimir P., Radenković, Saša P., Isenović, Esma R., "Serum nitric oxide levels correlate with quality of life questionnaires scores of hypothyroid females" in Medical Hypotheses, 131 (2019):109299, https://doi.org/10.1016/j.mehy.2019.109299 . .