Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes
Апстракт
Substitution reactions of the dinuclear Pt(II) complexes, [{Pt(en) Cl}(2)(mu-pz)](2+) (1), [{Pt(dach)Cl}(2) (mu-pz)](2)+ (2) and [{Pt(dach)Cl}(2)(mu-4,4-bipy)](2+) (3), and corresponding aqua analogs with selected biologically important ligands, viz. 1,2,4-triazole, L-histidine (L-His) and guanosine-5-monophosphate (5-GMP) were studied under pseudo-first-order conditions as a function of concentration and temperature using UV-vis spectrophotometry. The reactions of the chloride complexes were followed in aqueous 25 mmol L-1 Hepes buffer in the presence of 40 mmol L-1 NaCl at pH 7.2, whereas the reactions of the aqua complexes were studied at pH 2.5. Two consecutive reaction steps, which both depend on the nucleophile concentration, were observed in all cases. The second-order rate constants for both reaction steps indicate a decrease in the order 1 GT 2 GT 3 for all complexes. Also, the pKa values of all three aqua complexes were determined. The order of the reactivity of the studied l...igands is 1,2,4-triazole GT L-His GT 5-GMP. H-1 NMR spectroscopy and HPLC were used to follow the substitution of chloride in the dichloride 1, 2, and 3 complexes by guanosine-5-monophosphate (5-GMP). This study shows that the inert and bridging ligands have an important influence on the reactivity of the studied complexes.
Кључне речи:
Dinuclear Pt(II) complexes / Substitution / Kinetics / ReactivityИзвор:
Journal of Coordination Chemistry, 2015, 68, 17-18, 3148-3163Финансирање / пројекти:
- Испитивање механизма реакција комплекса јона прелазних метала са биолошки значајним молекулима (RS-MESTD-Basic Research (BR or ON)-172011)
DOI: 10.1080/00958972.2015.1048240
ISSN: 0095-8972; 1029-0389
WoS: 000361533600015
Scopus: 2-s2.0-84941417052
Колекције
Институција/група
VinčaTY - JOUR AU - Jovanović, Snežana AU - Bogojeski, Jovana V. AU - Petković, Marijana AU - Bugarčić, Živadin D. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/740 AB - Substitution reactions of the dinuclear Pt(II) complexes, [{Pt(en) Cl}(2)(mu-pz)](2+) (1), [{Pt(dach)Cl}(2) (mu-pz)](2)+ (2) and [{Pt(dach)Cl}(2)(mu-4,4-bipy)](2+) (3), and corresponding aqua analogs with selected biologically important ligands, viz. 1,2,4-triazole, L-histidine (L-His) and guanosine-5-monophosphate (5-GMP) were studied under pseudo-first-order conditions as a function of concentration and temperature using UV-vis spectrophotometry. The reactions of the chloride complexes were followed in aqueous 25 mmol L-1 Hepes buffer in the presence of 40 mmol L-1 NaCl at pH 7.2, whereas the reactions of the aqua complexes were studied at pH 2.5. Two consecutive reaction steps, which both depend on the nucleophile concentration, were observed in all cases. The second-order rate constants for both reaction steps indicate a decrease in the order 1 GT 2 GT 3 for all complexes. Also, the pKa values of all three aqua complexes were determined. The order of the reactivity of the studied ligands is 1,2,4-triazole GT L-His GT 5-GMP. H-1 NMR spectroscopy and HPLC were used to follow the substitution of chloride in the dichloride 1, 2, and 3 complexes by guanosine-5-monophosphate (5-GMP). This study shows that the inert and bridging ligands have an important influence on the reactivity of the studied complexes. T2 - Journal of Coordination Chemistry T1 - Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes VL - 68 IS - 17-18 SP - 3148 EP - 3163 DO - 10.1080/00958972.2015.1048240 ER -
@article{ author = "Jovanović, Snežana and Bogojeski, Jovana V. and Petković, Marijana and Bugarčić, Živadin D.", year = "2015", abstract = "Substitution reactions of the dinuclear Pt(II) complexes, [{Pt(en) Cl}(2)(mu-pz)](2+) (1), [{Pt(dach)Cl}(2) (mu-pz)](2)+ (2) and [{Pt(dach)Cl}(2)(mu-4,4-bipy)](2+) (3), and corresponding aqua analogs with selected biologically important ligands, viz. 1,2,4-triazole, L-histidine (L-His) and guanosine-5-monophosphate (5-GMP) were studied under pseudo-first-order conditions as a function of concentration and temperature using UV-vis spectrophotometry. The reactions of the chloride complexes were followed in aqueous 25 mmol L-1 Hepes buffer in the presence of 40 mmol L-1 NaCl at pH 7.2, whereas the reactions of the aqua complexes were studied at pH 2.5. Two consecutive reaction steps, which both depend on the nucleophile concentration, were observed in all cases. The second-order rate constants for both reaction steps indicate a decrease in the order 1 GT 2 GT 3 for all complexes. Also, the pKa values of all three aqua complexes were determined. The order of the reactivity of the studied ligands is 1,2,4-triazole GT L-His GT 5-GMP. H-1 NMR spectroscopy and HPLC were used to follow the substitution of chloride in the dichloride 1, 2, and 3 complexes by guanosine-5-monophosphate (5-GMP). This study shows that the inert and bridging ligands have an important influence on the reactivity of the studied complexes.", journal = "Journal of Coordination Chemistry", title = "Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes", volume = "68", number = "17-18", pages = "3148-3163", doi = "10.1080/00958972.2015.1048240" }
Jovanović, S., Bogojeski, J. V., Petković, M.,& Bugarčić, Ž. D.. (2015). Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes. in Journal of Coordination Chemistry, 68(17-18), 3148-3163. https://doi.org/10.1080/00958972.2015.1048240
Jovanović S, Bogojeski JV, Petković M, Bugarčić ŽD. Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes. in Journal of Coordination Chemistry. 2015;68(17-18):3148-3163. doi:10.1080/00958972.2015.1048240 .
Jovanović, Snežana, Bogojeski, Jovana V., Petković, Marijana, Bugarčić, Živadin D., "Interactions of nitrogen-donor bio-molecules with dinuclear platinum(II) complexes" in Journal of Coordination Chemistry, 68, no. 17-18 (2015):3148-3163, https://doi.org/10.1080/00958972.2015.1048240 . .