Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice
Само за регистроване кориснике
2013
Аутори
Radulović, Niko S.Zlatković, Dragan B.
Ranđelović, Pavle J.
Stojanović, Nikola M.
Novaković, Slađana B.
Akhlaghi, Hashem
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Ferula ovina (Boiss.) Boiss. is a traditional Iranian flavoring agent used as an ingredient of spices and condiments. Methods and results: GC-MS analyses of F. ovina aerial parts essential oil revealed the presence of a number of rare aromatic esters of monoterpenic alcohols. The structures of these esters were corroborated by synthesis, and one of them, bornyl 4-methoxybenzoate, turned out to be a new natural compound. The antinociceptive activities of the oil and the new ester were assessed in mice using several different laboratory models. The oil exerted strong peripheral and moderate central analgesic activities. Surprisingly, mice treated with bornyl 4-methoxybenzoate had an increased sensitivity to the noxious stimulus compared to that of the control group. A dynamic hot plate test was used to demonstrate that bornyl 4-methoxybenzoate induces hyperalgesia and not allodynia. Conclusion: Essential oil constituents impart this spice with both antinociceptive and hyperalgesic potent...ially flavor-related properties.
Извор:
Food and Function, 2013, 4, 12, 1751-1758Финансирање / пројекти:
DOI: 10.1039/c3fo60319a
ISSN: 2042-6496; 2042-650X
PubMed: 24113913
WoS: 000327462500003
Scopus: 2-s2.0-84888139762
Институција/група
VinčaTY - JOUR AU - Radulović, Niko S. AU - Zlatković, Dragan B. AU - Ranđelović, Pavle J. AU - Stojanović, Nikola M. AU - Novaković, Slađana B. AU - Akhlaghi, Hashem PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5766 AB - Ferula ovina (Boiss.) Boiss. is a traditional Iranian flavoring agent used as an ingredient of spices and condiments. Methods and results: GC-MS analyses of F. ovina aerial parts essential oil revealed the presence of a number of rare aromatic esters of monoterpenic alcohols. The structures of these esters were corroborated by synthesis, and one of them, bornyl 4-methoxybenzoate, turned out to be a new natural compound. The antinociceptive activities of the oil and the new ester were assessed in mice using several different laboratory models. The oil exerted strong peripheral and moderate central analgesic activities. Surprisingly, mice treated with bornyl 4-methoxybenzoate had an increased sensitivity to the noxious stimulus compared to that of the control group. A dynamic hot plate test was used to demonstrate that bornyl 4-methoxybenzoate induces hyperalgesia and not allodynia. Conclusion: Essential oil constituents impart this spice with both antinociceptive and hyperalgesic potentially flavor-related properties. T2 - Food and Function T1 - Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice VL - 4 IS - 12 SP - 1751 EP - 1758 DO - 10.1039/c3fo60319a ER -
@article{ author = "Radulović, Niko S. and Zlatković, Dragan B. and Ranđelović, Pavle J. and Stojanović, Nikola M. and Novaković, Slađana B. and Akhlaghi, Hashem", year = "2013", abstract = "Ferula ovina (Boiss.) Boiss. is a traditional Iranian flavoring agent used as an ingredient of spices and condiments. Methods and results: GC-MS analyses of F. ovina aerial parts essential oil revealed the presence of a number of rare aromatic esters of monoterpenic alcohols. The structures of these esters were corroborated by synthesis, and one of them, bornyl 4-methoxybenzoate, turned out to be a new natural compound. The antinociceptive activities of the oil and the new ester were assessed in mice using several different laboratory models. The oil exerted strong peripheral and moderate central analgesic activities. Surprisingly, mice treated with bornyl 4-methoxybenzoate had an increased sensitivity to the noxious stimulus compared to that of the control group. A dynamic hot plate test was used to demonstrate that bornyl 4-methoxybenzoate induces hyperalgesia and not allodynia. Conclusion: Essential oil constituents impart this spice with both antinociceptive and hyperalgesic potentially flavor-related properties.", journal = "Food and Function", title = "Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice", volume = "4", number = "12", pages = "1751-1758", doi = "10.1039/c3fo60319a" }
Radulović, N. S., Zlatković, D. B., Ranđelović, P. J., Stojanović, N. M., Novaković, S. B.,& Akhlaghi, H.. (2013). Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice. in Food and Function, 4(12), 1751-1758. https://doi.org/10.1039/c3fo60319a
Radulović NS, Zlatković DB, Ranđelović PJ, Stojanović NM, Novaković SB, Akhlaghi H. Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice. in Food and Function. 2013;4(12):1751-1758. doi:10.1039/c3fo60319a .
Radulović, Niko S., Zlatković, Dragan B., Ranđelović, Pavle J., Stojanović, Nikola M., Novaković, Slađana B., Akhlaghi, Hashem, "Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice" in Food and Function, 4, no. 12 (2013):1751-1758, https://doi.org/10.1039/c3fo60319a . .