Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats
2013
Аутори
Gavrilović, LjubicaStojiljković, Vesna
Kasapović, Jelena
Popović, Nataša M.
Pajović, Snežana B.
Dronjak, Slađana
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Chronic isolation of adult animals represents a form of psychological stress that produces sympatho-adrenomedullar activation. Exercise training acts as an important modulator of sympatho-adrenomedullary system. This study aimed to investigate physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase) and cyclic adenosine monophosphate response element-binding (CREB) in the adrenal medulla, concentrations of catecholamines and corticosterone (CORT) in the plasma and the weight of adrenal glands of chronically psychosocially stressed adult rats exposed daily to 20 min treadmill running for 12 weeks, Also, we examined how additional acute immobilization stress changes the mentioned parameters. Treadmill running did not result in modulation of gene expression of catecholamine synthesizing enzymes and it decreased the level of CREB mRNA in the adrenal medulla of chro...nically psychosocially stressed adult rats. The potentially negative physiological adaptations after treadmill running were recorded as increased concentrations of catecholamines and decreased morning CORT concentration in the plasma, as well as the adrenal gland hypertrophy of chronically psychosocially stressed rats. The additional acute immobilization stress increases gene expression of catecholamine biosynthetic enzymes in the adrenal medulla, as well as catecholamines and CORT levels in the plasma. Treadmill exercise does not change the activity of sympatho-adrenomedullary system of chronically psychosocially stressed rats.
Кључне речи:
adrenal medulla / acute immobilization stress / catecholamine / chronic social isolation / gene expression / treadmill exerciseИзвор:
Anais de Academia Brasileira de Ciencias, 2013, 85, 3, 999-1012Финансирање / пројекти:
- Ћелијске и молекулске основе малигних и кардиоваскуларних обољења-клиничке импликације (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41027)
- Акутни коронарни синдром: истраживање вулнерабилности (плака, крви и миокарда), оптимално лечење и одређивање прогностичких фактора (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41022)
- Молекуларни механизми патофизиолошких промена у ћелијама централног нервног система и периферног ткива код сисара (RS-MESTD-Basic Research (BR or ON)-173044)
DOI: 10.1590/S0001-37652013005000041
ISSN: 0001-3765
PubMed: 23903565
WoS: 000324948400016
Scopus: 2-s2.0-84884228561
Колекције
Институција/група
VinčaTY - JOUR AU - Gavrilović, Ljubica AU - Stojiljković, Vesna AU - Kasapović, Jelena AU - Popović, Nataša M. AU - Pajović, Snežana B. AU - Dronjak, Slađana PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/5703 AB - Chronic isolation of adult animals represents a form of psychological stress that produces sympatho-adrenomedullar activation. Exercise training acts as an important modulator of sympatho-adrenomedullary system. This study aimed to investigate physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase) and cyclic adenosine monophosphate response element-binding (CREB) in the adrenal medulla, concentrations of catecholamines and corticosterone (CORT) in the plasma and the weight of adrenal glands of chronically psychosocially stressed adult rats exposed daily to 20 min treadmill running for 12 weeks, Also, we examined how additional acute immobilization stress changes the mentioned parameters. Treadmill running did not result in modulation of gene expression of catecholamine synthesizing enzymes and it decreased the level of CREB mRNA in the adrenal medulla of chronically psychosocially stressed adult rats. The potentially negative physiological adaptations after treadmill running were recorded as increased concentrations of catecholamines and decreased morning CORT concentration in the plasma, as well as the adrenal gland hypertrophy of chronically psychosocially stressed rats. The additional acute immobilization stress increases gene expression of catecholamine biosynthetic enzymes in the adrenal medulla, as well as catecholamines and CORT levels in the plasma. Treadmill exercise does not change the activity of sympatho-adrenomedullary system of chronically psychosocially stressed rats. T2 - Anais de Academia Brasileira de Ciencias T1 - Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats VL - 85 IS - 3 SP - 999 EP - 1012 DO - 10.1590/S0001-37652013005000041 ER -
@article{ author = "Gavrilović, Ljubica and Stojiljković, Vesna and Kasapović, Jelena and Popović, Nataša M. and Pajović, Snežana B. and Dronjak, Slađana", year = "2013", abstract = "Chronic isolation of adult animals represents a form of psychological stress that produces sympatho-adrenomedullar activation. Exercise training acts as an important modulator of sympatho-adrenomedullary system. This study aimed to investigate physical exercise-related changes in gene expression of catecholamine biosynthetic enzymes (tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase) and cyclic adenosine monophosphate response element-binding (CREB) in the adrenal medulla, concentrations of catecholamines and corticosterone (CORT) in the plasma and the weight of adrenal glands of chronically psychosocially stressed adult rats exposed daily to 20 min treadmill running for 12 weeks, Also, we examined how additional acute immobilization stress changes the mentioned parameters. Treadmill running did not result in modulation of gene expression of catecholamine synthesizing enzymes and it decreased the level of CREB mRNA in the adrenal medulla of chronically psychosocially stressed adult rats. The potentially negative physiological adaptations after treadmill running were recorded as increased concentrations of catecholamines and decreased morning CORT concentration in the plasma, as well as the adrenal gland hypertrophy of chronically psychosocially stressed rats. The additional acute immobilization stress increases gene expression of catecholamine biosynthetic enzymes in the adrenal medulla, as well as catecholamines and CORT levels in the plasma. Treadmill exercise does not change the activity of sympatho-adrenomedullary system of chronically psychosocially stressed rats.", journal = "Anais de Academia Brasileira de Ciencias", title = "Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats", volume = "85", number = "3", pages = "999-1012", doi = "10.1590/S0001-37652013005000041" }
Gavrilović, L., Stojiljković, V., Kasapović, J., Popović, N. M., Pajović, S. B.,& Dronjak, S.. (2013). Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats. in Anais de Academia Brasileira de Ciencias, 85(3), 999-1012. https://doi.org/10.1590/S0001-37652013005000041
Gavrilović L, Stojiljković V, Kasapović J, Popović NM, Pajović SB, Dronjak S. Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats. in Anais de Academia Brasileira de Ciencias. 2013;85(3):999-1012. doi:10.1590/S0001-37652013005000041 .
Gavrilović, Ljubica, Stojiljković, Vesna, Kasapović, Jelena, Popović, Nataša M., Pajović, Snežana B., Dronjak, Slađana, "Treadmill exercise does not change gene expression of adrenal catecholamine biosynthetic enzymes in chronically stressed rats" in Anais de Academia Brasileira de Ciencias, 85, no. 3 (2013):999-1012, https://doi.org/10.1590/S0001-37652013005000041 . .