FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions
Апстракт
This review surveys the soft ionisation mass spectrometric methods that are most commonly used for the investigation of the mechanism of interaction between metallo-drugs and biomolecules. In the first part of the review, an overview of the applications of transition metal complexes in the therapy of various diseases (arthritis, cancer, diabetes) is given, whereas the second part focuses on the obtained results dealing with various aspects of the interaction between metal complexes and different types of biomolecules. Possibilities and limitations of each mass spectrometric method-namely, fast atom bombardment (FAB), electrospray ionisation (ESI) and matrix-assisted laser desorption and ionisation (MALDI)-are discussed in the third part of this review along with the examples of their application for the analysis of metal complexes, as well as of the products of their interaction with biomolecules.
Извор:
Metallomics, 2011, 3, 6, 550-565Финансирање / пројекти:
- Испитивање механизма реакција комплекса јона прелазних метала са биолошки значајним молекулима (RS-MESTD-Basic Research (BR or ON)-172011)
DOI: 10.1039/c0mt00096e
ISSN: 1756-5901; 1756-591X
PubMed: 21483900
WoS: 000291350500002
Scopus: 2-s2.0-79959225015
Колекције
Институција/група
VinčaTY - JOUR AU - Petković, Marijana AU - Kamceva, Tina PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4336 AB - This review surveys the soft ionisation mass spectrometric methods that are most commonly used for the investigation of the mechanism of interaction between metallo-drugs and biomolecules. In the first part of the review, an overview of the applications of transition metal complexes in the therapy of various diseases (arthritis, cancer, diabetes) is given, whereas the second part focuses on the obtained results dealing with various aspects of the interaction between metal complexes and different types of biomolecules. Possibilities and limitations of each mass spectrometric method-namely, fast atom bombardment (FAB), electrospray ionisation (ESI) and matrix-assisted laser desorption and ionisation (MALDI)-are discussed in the third part of this review along with the examples of their application for the analysis of metal complexes, as well as of the products of their interaction with biomolecules. T2 - Metallomics T1 - FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions VL - 3 IS - 6 SP - 550 EP - 565 DO - 10.1039/c0mt00096e ER -
@article{ author = "Petković, Marijana and Kamceva, Tina", year = "2011", abstract = "This review surveys the soft ionisation mass spectrometric methods that are most commonly used for the investigation of the mechanism of interaction between metallo-drugs and biomolecules. In the first part of the review, an overview of the applications of transition metal complexes in the therapy of various diseases (arthritis, cancer, diabetes) is given, whereas the second part focuses on the obtained results dealing with various aspects of the interaction between metal complexes and different types of biomolecules. Possibilities and limitations of each mass spectrometric method-namely, fast atom bombardment (FAB), electrospray ionisation (ESI) and matrix-assisted laser desorption and ionisation (MALDI)-are discussed in the third part of this review along with the examples of their application for the analysis of metal complexes, as well as of the products of their interaction with biomolecules.", journal = "Metallomics", title = "FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions", volume = "3", number = "6", pages = "550-565", doi = "10.1039/c0mt00096e" }
Petković, M.,& Kamceva, T.. (2011). FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions. in Metallomics, 3(6), 550-565. https://doi.org/10.1039/c0mt00096e
Petković M, Kamceva T. FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions. in Metallomics. 2011;3(6):550-565. doi:10.1039/c0mt00096e .
Petković, Marijana, Kamceva, Tina, "FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions" in Metallomics, 3, no. 6 (2011):550-565, https://doi.org/10.1039/c0mt00096e . .