Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans
Нема приказа
Аутори
Stanković, AleksandraDinčić, Evica
Ristić, Smiljana
Lovrečić, Luca
Starčević Čizmarević, Nada
Đurić, Tamara
Sepčić, Juraj
Kapović, Miljenko
Raičević, Ranko
Peterlin, Borut
Alavantić, Dragan
Živković, Maja
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
The interleukin 7 receptor alpha single nucleotide polymorphism rs6897932 was identified as a multiple sclerosis susceptibility-modifying polymorphism in genome-wide and gene scan studies, mainly in populations in western countries. The aim of this study was to investigate the association of interleukin 7 receptor alpha rs6897932 with multiple sclerosis in populations from the Western Balkans: Serbia, Croatia, and Slovenia. A total of 678 unrelated white patients and 597 unrelated, ethnically matched healthy controls were included in the study. Genotyping was performed by real-time polymerase chain reaction. We found no significant difference in genotype or allele frequencies between controls and patients with multiple sclerosis either separately in Serbian, Croatian, and Slovenian populations or in the whole sample from the Western Balkans. The odds ratio for multiple sclerosis in this study was 1.04 (0.86-1.25) for the C allele. It is known that demographic as well as environmental f...actors have a substantial role in multiple sclerosis development, as well as population genetic background. The results of this study indicate that other types of genome variants should be required for the development and/or progression of multiple sclerosis, which may vary among populations.
Кључне речи:
Interleukin 7 receptor-alpha / rs6897932 / gene polymorphism / multiple sclerosis / Western BalkansИзвор:
Multiple Sclerosis Journal, 2010, 16, 5, 533-536Финансирање / пројекти:
- Serbian Ministry of Science and Technology [M145023], Ministry of Science, Education and Sports of the Republic of Croatia [062-1962766-0470], Ministry of Science and Technology, Republic of Slovenia
DOI: 10.1177/1352458509360548
ISSN: 1352-4585
PubMed: 20194581
WoS: 000277837200005
Scopus: 2-s2.0-77952842147
Колекције
Институција/група
VinčaTY - JOUR AU - Stanković, Aleksandra AU - Dinčić, Evica AU - Ristić, Smiljana AU - Lovrečić, Luca AU - Starčević Čizmarević, Nada AU - Đurić, Tamara AU - Sepčić, Juraj AU - Kapović, Miljenko AU - Raičević, Ranko AU - Peterlin, Borut AU - Alavantić, Dragan AU - Živković, Maja PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4004 AB - The interleukin 7 receptor alpha single nucleotide polymorphism rs6897932 was identified as a multiple sclerosis susceptibility-modifying polymorphism in genome-wide and gene scan studies, mainly in populations in western countries. The aim of this study was to investigate the association of interleukin 7 receptor alpha rs6897932 with multiple sclerosis in populations from the Western Balkans: Serbia, Croatia, and Slovenia. A total of 678 unrelated white patients and 597 unrelated, ethnically matched healthy controls were included in the study. Genotyping was performed by real-time polymerase chain reaction. We found no significant difference in genotype or allele frequencies between controls and patients with multiple sclerosis either separately in Serbian, Croatian, and Slovenian populations or in the whole sample from the Western Balkans. The odds ratio for multiple sclerosis in this study was 1.04 (0.86-1.25) for the C allele. It is known that demographic as well as environmental factors have a substantial role in multiple sclerosis development, as well as population genetic background. The results of this study indicate that other types of genome variants should be required for the development and/or progression of multiple sclerosis, which may vary among populations. T2 - Multiple Sclerosis Journal T1 - Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans VL - 16 IS - 5 SP - 533 EP - 536 DO - 10.1177/1352458509360548 ER -
@article{ author = "Stanković, Aleksandra and Dinčić, Evica and Ristić, Smiljana and Lovrečić, Luca and Starčević Čizmarević, Nada and Đurić, Tamara and Sepčić, Juraj and Kapović, Miljenko and Raičević, Ranko and Peterlin, Borut and Alavantić, Dragan and Živković, Maja", year = "2010", abstract = "The interleukin 7 receptor alpha single nucleotide polymorphism rs6897932 was identified as a multiple sclerosis susceptibility-modifying polymorphism in genome-wide and gene scan studies, mainly in populations in western countries. The aim of this study was to investigate the association of interleukin 7 receptor alpha rs6897932 with multiple sclerosis in populations from the Western Balkans: Serbia, Croatia, and Slovenia. A total of 678 unrelated white patients and 597 unrelated, ethnically matched healthy controls were included in the study. Genotyping was performed by real-time polymerase chain reaction. We found no significant difference in genotype or allele frequencies between controls and patients with multiple sclerosis either separately in Serbian, Croatian, and Slovenian populations or in the whole sample from the Western Balkans. The odds ratio for multiple sclerosis in this study was 1.04 (0.86-1.25) for the C allele. It is known that demographic as well as environmental factors have a substantial role in multiple sclerosis development, as well as population genetic background. The results of this study indicate that other types of genome variants should be required for the development and/or progression of multiple sclerosis, which may vary among populations.", journal = "Multiple Sclerosis Journal", title = "Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans", volume = "16", number = "5", pages = "533-536", doi = "10.1177/1352458509360548" }
Stanković, A., Dinčić, E., Ristić, S., Lovrečić, L., Starčević Čizmarević, N., Đurić, T., Sepčić, J., Kapović, M., Raičević, R., Peterlin, B., Alavantić, D.,& Živković, M.. (2010). Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans. in Multiple Sclerosis Journal, 16(5), 533-536. https://doi.org/10.1177/1352458509360548
Stanković A, Dinčić E, Ristić S, Lovrečić L, Starčević Čizmarević N, Đurić T, Sepčić J, Kapović M, Raičević R, Peterlin B, Alavantić D, Živković M. Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans. in Multiple Sclerosis Journal. 2010;16(5):533-536. doi:10.1177/1352458509360548 .
Stanković, Aleksandra, Dinčić, Evica, Ristić, Smiljana, Lovrečić, Luca, Starčević Čizmarević, Nada, Đurić, Tamara, Sepčić, Juraj, Kapović, Miljenko, Raičević, Ranko, Peterlin, Borut, Alavantić, Dragan, Živković, Maja, "Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans" in Multiple Sclerosis Journal, 16, no. 5 (2010):533-536, https://doi.org/10.1177/1352458509360548 . .