Interactive Effects of Insulin and beta-Estradiol on Protein Kinase B Phosphorylation in Adult Rat Cardiomyocytes
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Аутори
Sudar, EminaDobutović, Branislava
Milosavljević, Tijana
Putniković, Biljana
Gluvić, Zoran
Isenović, Esma R.
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Insulin (INS) and beta-estradiol (E(2)) have vascular effects partially through stimulation of protein kinase B (Akt) phosphorylation. Employing adult rat cardiomyocytes (ARC), the effects of acute (15 min) stimulation with INS (10 mIU/ml) and prolonged (2 hours and 24 hours) stimulation with E(2) alone or in combination, were assessed with respect to protein levels of Akt. Exposure to INS for 15 minutes enhanced Akt Ser(473) phosphorylation. The combined treatment had a greater effect on Akt phosphorylation then the effect of INS alone. The results suggest that INS and E(2) may interact through Akt in regulating metabolic processes.
Кључне речи:
Adult rat cardiomyocytes / insulin / estradiol / signaling pathways / protein kinase BИзвор:
Acta Chimica Slovenica, 2009, 56, 3, 723-728Финансирање / пројекти:
- Ministry of Science, Republic of Serbia [143030]
Колекције
Институција/група
VinčaTY - JOUR AU - Sudar, Emina AU - Dobutović, Branislava AU - Milosavljević, Tijana AU - Putniković, Biljana AU - Gluvić, Zoran AU - Isenović, Esma R. PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3804 AB - Insulin (INS) and beta-estradiol (E(2)) have vascular effects partially through stimulation of protein kinase B (Akt) phosphorylation. Employing adult rat cardiomyocytes (ARC), the effects of acute (15 min) stimulation with INS (10 mIU/ml) and prolonged (2 hours and 24 hours) stimulation with E(2) alone or in combination, were assessed with respect to protein levels of Akt. Exposure to INS for 15 minutes enhanced Akt Ser(473) phosphorylation. The combined treatment had a greater effect on Akt phosphorylation then the effect of INS alone. The results suggest that INS and E(2) may interact through Akt in regulating metabolic processes. T2 - Acta Chimica Slovenica T1 - Interactive Effects of Insulin and beta-Estradiol on Protein Kinase B Phosphorylation in Adult Rat Cardiomyocytes VL - 56 IS - 3 SP - 723 EP - 728 UR - https://hdl.handle.net/21.15107/rcub_vinar_3804 ER -
@article{ author = "Sudar, Emina and Dobutović, Branislava and Milosavljević, Tijana and Putniković, Biljana and Gluvić, Zoran and Isenović, Esma R.", year = "2009", abstract = "Insulin (INS) and beta-estradiol (E(2)) have vascular effects partially through stimulation of protein kinase B (Akt) phosphorylation. Employing adult rat cardiomyocytes (ARC), the effects of acute (15 min) stimulation with INS (10 mIU/ml) and prolonged (2 hours and 24 hours) stimulation with E(2) alone or in combination, were assessed with respect to protein levels of Akt. Exposure to INS for 15 minutes enhanced Akt Ser(473) phosphorylation. The combined treatment had a greater effect on Akt phosphorylation then the effect of INS alone. The results suggest that INS and E(2) may interact through Akt in regulating metabolic processes.", journal = "Acta Chimica Slovenica", title = "Interactive Effects of Insulin and beta-Estradiol on Protein Kinase B Phosphorylation in Adult Rat Cardiomyocytes", volume = "56", number = "3", pages = "723-728", url = "https://hdl.handle.net/21.15107/rcub_vinar_3804" }
Sudar, E., Dobutović, B., Milosavljević, T., Putniković, B., Gluvić, Z.,& Isenović, E. R.. (2009). Interactive Effects of Insulin and beta-Estradiol on Protein Kinase B Phosphorylation in Adult Rat Cardiomyocytes. in Acta Chimica Slovenica, 56(3), 723-728. https://hdl.handle.net/21.15107/rcub_vinar_3804
Sudar E, Dobutović B, Milosavljević T, Putniković B, Gluvić Z, Isenović ER. Interactive Effects of Insulin and beta-Estradiol on Protein Kinase B Phosphorylation in Adult Rat Cardiomyocytes. in Acta Chimica Slovenica. 2009;56(3):723-728. https://hdl.handle.net/21.15107/rcub_vinar_3804 .
Sudar, Emina, Dobutović, Branislava, Milosavljević, Tijana, Putniković, Biljana, Gluvić, Zoran, Isenović, Esma R., "Interactive Effects of Insulin and beta-Estradiol on Protein Kinase B Phosphorylation in Adult Rat Cardiomyocytes" in Acta Chimica Slovenica, 56, no. 3 (2009):723-728, https://hdl.handle.net/21.15107/rcub_vinar_3804 .