Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats
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In the present study, we examined gross changes in the mass of whole adrenal glands and that of the adrenal cortex and medulla in mature male Wistar rats subjected to three different stress types: acute, chronic, and combined, i.e., chronic followed by acute stress. These parameters were correlated with adrenal activity as judged from serum levels of corticosterone and catecholamines, respectively, as well as with serum levels of ACTH and glucose. Under all three conditions, we observed bilaterally asymmetric and stress-type-independent hypertrophy of whole adrenals, as well as adrenal cortices and medullas. Under acute and combined stress, adrenal hypertrophy was followed by increase of adrenal hormones in the blood serum. However, under chronic stress, both cortical and medullar activities as judged from low or unaltered levels of the respective hormones and glucose were compromised and disconnected from the input signal of ACTH. Since all of the studied adrenal activities could be r...estored by subsequent acute stress, it is concluded that chronic isolation can be viewed as partly maladaptive stress with characteristics resembling stress resistance rather than the stress exhaustion stage of the general adaptation syndrome.
Кључне речи:
Wistar rats / immobilization / isolation / adrenal glands / adrenal hormones / stressИзвор:
Archives of Biological Sciences, 2009, 61, 2, 187-194Финансирање / пројекти:
- Ministry of Science of Serbia [143042B]
DOI: 10.2298/ABS0902187A
ISSN: 0354-4664
WoS: 000268316000005
Scopus: 2-s2.0-67849104171
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Институција/група
VinčaTY - JOUR AU - Adžić, Miroslav AU - Đorđević, Ana D. AU - Đorđević, Jelena D. AU - Nićiforović, Ana AU - Radojčić, Marija PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3750 AB - In the present study, we examined gross changes in the mass of whole adrenal glands and that of the adrenal cortex and medulla in mature male Wistar rats subjected to three different stress types: acute, chronic, and combined, i.e., chronic followed by acute stress. These parameters were correlated with adrenal activity as judged from serum levels of corticosterone and catecholamines, respectively, as well as with serum levels of ACTH and glucose. Under all three conditions, we observed bilaterally asymmetric and stress-type-independent hypertrophy of whole adrenals, as well as adrenal cortices and medullas. Under acute and combined stress, adrenal hypertrophy was followed by increase of adrenal hormones in the blood serum. However, under chronic stress, both cortical and medullar activities as judged from low or unaltered levels of the respective hormones and glucose were compromised and disconnected from the input signal of ACTH. Since all of the studied adrenal activities could be restored by subsequent acute stress, it is concluded that chronic isolation can be viewed as partly maladaptive stress with characteristics resembling stress resistance rather than the stress exhaustion stage of the general adaptation syndrome. T2 - Archives of Biological Sciences T1 - Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats VL - 61 IS - 2 SP - 187 EP - 194 DO - 10.2298/ABS0902187A ER -
@article{ author = "Adžić, Miroslav and Đorđević, Ana D. and Đorđević, Jelena D. and Nićiforović, Ana and Radojčić, Marija", year = "2009", abstract = "In the present study, we examined gross changes in the mass of whole adrenal glands and that of the adrenal cortex and medulla in mature male Wistar rats subjected to three different stress types: acute, chronic, and combined, i.e., chronic followed by acute stress. These parameters were correlated with adrenal activity as judged from serum levels of corticosterone and catecholamines, respectively, as well as with serum levels of ACTH and glucose. Under all three conditions, we observed bilaterally asymmetric and stress-type-independent hypertrophy of whole adrenals, as well as adrenal cortices and medullas. Under acute and combined stress, adrenal hypertrophy was followed by increase of adrenal hormones in the blood serum. However, under chronic stress, both cortical and medullar activities as judged from low or unaltered levels of the respective hormones and glucose were compromised and disconnected from the input signal of ACTH. Since all of the studied adrenal activities could be restored by subsequent acute stress, it is concluded that chronic isolation can be viewed as partly maladaptive stress with characteristics resembling stress resistance rather than the stress exhaustion stage of the general adaptation syndrome.", journal = "Archives of Biological Sciences", title = "Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats", volume = "61", number = "2", pages = "187-194", doi = "10.2298/ABS0902187A" }
Adžić, M., Đorđević, A. D., Đorđević, J. D., Nićiforović, A.,& Radojčić, M.. (2009). Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats. in Archives of Biological Sciences, 61(2), 187-194. https://doi.org/10.2298/ABS0902187A
Adžić M, Đorđević AD, Đorđević JD, Nićiforović A, Radojčić M. Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats. in Archives of Biological Sciences. 2009;61(2):187-194. doi:10.2298/ABS0902187A .
Adžić, Miroslav, Đorđević, Ana D., Đorđević, Jelena D., Nićiforović, Ana, Radojčić, Marija, "Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats" in Archives of Biological Sciences, 61, no. 2 (2009):187-194, https://doi.org/10.2298/ABS0902187A . .