Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease
2007
Аутори
Stanković, AleksandraStanković, Sanja
Jovanovic-Markovic, Zagorka
Živković, Maja
Đurić, Tamara
Glišić, Sanja
Alavantić, Dragan
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P LT 0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P LT 0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P LT 0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.
Кључне речи:
ApoB / ischemic cerebrovascular disease / gene / polymorphism / human population / SerbiaИзвор:
Archives of Biological Sciences, 2007, 59, 4, 303-309Финансирање / пројекти:
- Генетска eпидемиологија и фармакогеномика васкуларних обољења (RS-MESTD-MPN2006-2010-145023)
Институција/група
VinčaTY - JOUR AU - Stanković, Aleksandra AU - Stanković, Sanja AU - Jovanovic-Markovic, Zagorka AU - Živković, Maja AU - Đurić, Tamara AU - Glišić, Sanja AU - Alavantić, Dragan PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3419 AB - The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P LT 0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P LT 0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P LT 0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk. T2 - Archives of Biological Sciences T1 - Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease VL - 59 IS - 4 SP - 303 EP - 309 DO - 10.2298/ABS0704303S ER -
@article{ author = "Stanković, Aleksandra and Stanković, Sanja and Jovanovic-Markovic, Zagorka and Živković, Maja and Đurić, Tamara and Glišić, Sanja and Alavantić, Dragan", year = "2007", abstract = "The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (Xbal, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P LT 0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P LT 0.05). The patients had significantly higher frequency of the 4311 A allele compared to the controls (P LT 0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.", journal = "Archives of Biological Sciences", title = "Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease", volume = "59", number = "4", pages = "303-309", doi = "10.2298/ABS0704303S" }
Stanković, A., Stanković, S., Jovanovic-Markovic, Z., Živković, M., Đurić, T., Glišić, S.,& Alavantić, D.. (2007). Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease. in Archives of Biological Sciences, 59(4), 303-309. https://doi.org/10.2298/ABS0704303S
Stanković A, Stanković S, Jovanovic-Markovic Z, Živković M, Đurić T, Glišić S, Alavantić D. Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease. in Archives of Biological Sciences. 2007;59(4):303-309. doi:10.2298/ABS0704303S .
Stanković, Aleksandra, Stanković, Sanja, Jovanovic-Markovic, Zagorka, Živković, Maja, Đurić, Tamara, Glišić, Sanja, Alavantić, Dragan, "Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease" in Archives of Biological Sciences, 59, no. 4 (2007):303-309, https://doi.org/10.2298/ABS0704303S . .