Effects of dexamethasone on insulin receptor in aging
Нема приказа
Аутори
Korićanac, GoranStojiljković, Mojca D.
Radivojša, Snežana
Žakula, Zorica
Ribarac-Stepić, Nevena B.
Isenović, Esma R.
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to examine the effects of dexamethasone (Dex) on functional properties of the rat insulin receptor (IR). Male Mill Hill hooded rats, 3, 6, 12, 18 and 21 months old, were injected with Dex (4 mg/kg) and rat liver and erythrocytes were used for experiments 18 h after Dex administration. Treatment with Dex lowered the specific binding (SB) of insulin ( INS) in the liver of 3- and 18-month-old rats and concentration of INS binding sites (N-1, N-2) and the dissociation constant of low-affinity binding sites (Kd(2)) in the liver of 6- and 18-month-old rats. In addition, Dex treatment lowered the liver IR protein level in all analyzed groups, except 21-month-old rats where it remained unchanged, but raised the IR mRNA level in 18-month-old rats. In erythrocytes, treatment with Dex decreased SB and Kd2 ( in animals 3 and 6 months old) and N1 ( in ones 3 and 18 months old). Following Dex treatment, the INS plasma level increased ( in rats 3, 18 and 21 months old), whil...e glucose (Glu) concentration increased in 3 and 12 months old, but decreased in 6- and 21-month-old rats. In summary, Dex exerts the strongest effect on the erythrocyte IR of 3- and 6- month-old rats and the hepatic IR of 18-month-old rats. IR in both tissues is almost insensitive to Dex in 12- and 21-month-old rats. The pattern of age-related changes of IR induced by Dex does not correlate with changes of plasma Glu and INS.
Кључне речи:
dexamethasone / insulin receptor / aging / liver / erythrocytesИзвор:
Acta Biologica Hungarica, 2008, 59, 1, 17-29
DOI: 10.1556/ABiol.59.2008.1.2
ISSN: 0236-5383
PubMed: 18401942
WoS: 000253256600002
Scopus: 2-s2.0-40049103577
Колекције
Институција/група
VinčaTY - JOUR AU - Korićanac, Goran AU - Stojiljković, Mojca D. AU - Radivojša, Snežana AU - Žakula, Zorica AU - Ribarac-Stepić, Nevena B. AU - Isenović, Esma R. PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3365 AB - The aim of this study was to examine the effects of dexamethasone (Dex) on functional properties of the rat insulin receptor (IR). Male Mill Hill hooded rats, 3, 6, 12, 18 and 21 months old, were injected with Dex (4 mg/kg) and rat liver and erythrocytes were used for experiments 18 h after Dex administration. Treatment with Dex lowered the specific binding (SB) of insulin ( INS) in the liver of 3- and 18-month-old rats and concentration of INS binding sites (N-1, N-2) and the dissociation constant of low-affinity binding sites (Kd(2)) in the liver of 6- and 18-month-old rats. In addition, Dex treatment lowered the liver IR protein level in all analyzed groups, except 21-month-old rats where it remained unchanged, but raised the IR mRNA level in 18-month-old rats. In erythrocytes, treatment with Dex decreased SB and Kd2 ( in animals 3 and 6 months old) and N1 ( in ones 3 and 18 months old). Following Dex treatment, the INS plasma level increased ( in rats 3, 18 and 21 months old), while glucose (Glu) concentration increased in 3 and 12 months old, but decreased in 6- and 21-month-old rats. In summary, Dex exerts the strongest effect on the erythrocyte IR of 3- and 6- month-old rats and the hepatic IR of 18-month-old rats. IR in both tissues is almost insensitive to Dex in 12- and 21-month-old rats. The pattern of age-related changes of IR induced by Dex does not correlate with changes of plasma Glu and INS. T2 - Acta Biologica Hungarica T1 - Effects of dexamethasone on insulin receptor in aging VL - 59 IS - 1 SP - 17 EP - 29 DO - 10.1556/ABiol.59.2008.1.2 ER -
@article{ author = "Korićanac, Goran and Stojiljković, Mojca D. and Radivojša, Snežana and Žakula, Zorica and Ribarac-Stepić, Nevena B. and Isenović, Esma R.", year = "2008", abstract = "The aim of this study was to examine the effects of dexamethasone (Dex) on functional properties of the rat insulin receptor (IR). Male Mill Hill hooded rats, 3, 6, 12, 18 and 21 months old, were injected with Dex (4 mg/kg) and rat liver and erythrocytes were used for experiments 18 h after Dex administration. Treatment with Dex lowered the specific binding (SB) of insulin ( INS) in the liver of 3- and 18-month-old rats and concentration of INS binding sites (N-1, N-2) and the dissociation constant of low-affinity binding sites (Kd(2)) in the liver of 6- and 18-month-old rats. In addition, Dex treatment lowered the liver IR protein level in all analyzed groups, except 21-month-old rats where it remained unchanged, but raised the IR mRNA level in 18-month-old rats. In erythrocytes, treatment with Dex decreased SB and Kd2 ( in animals 3 and 6 months old) and N1 ( in ones 3 and 18 months old). Following Dex treatment, the INS plasma level increased ( in rats 3, 18 and 21 months old), while glucose (Glu) concentration increased in 3 and 12 months old, but decreased in 6- and 21-month-old rats. In summary, Dex exerts the strongest effect on the erythrocyte IR of 3- and 6- month-old rats and the hepatic IR of 18-month-old rats. IR in both tissues is almost insensitive to Dex in 12- and 21-month-old rats. The pattern of age-related changes of IR induced by Dex does not correlate with changes of plasma Glu and INS.", journal = "Acta Biologica Hungarica", title = "Effects of dexamethasone on insulin receptor in aging", volume = "59", number = "1", pages = "17-29", doi = "10.1556/ABiol.59.2008.1.2" }
Korićanac, G., Stojiljković, M. D., Radivojša, S., Žakula, Z., Ribarac-Stepić, N. B.,& Isenović, E. R.. (2008). Effects of dexamethasone on insulin receptor in aging. in Acta Biologica Hungarica, 59(1), 17-29. https://doi.org/10.1556/ABiol.59.2008.1.2
Korićanac G, Stojiljković MD, Radivojša S, Žakula Z, Ribarac-Stepić NB, Isenović ER. Effects of dexamethasone on insulin receptor in aging. in Acta Biologica Hungarica. 2008;59(1):17-29. doi:10.1556/ABiol.59.2008.1.2 .
Korićanac, Goran, Stojiljković, Mojca D., Radivojša, Snežana, Žakula, Zorica, Ribarac-Stepić, Nevena B., Isenović, Esma R., "Effects of dexamethasone on insulin receptor in aging" in Acta Biologica Hungarica, 59, no. 1 (2008):17-29, https://doi.org/10.1556/ABiol.59.2008.1.2 . .