Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease
Само за регистроване кориснике
2008
Аутори
Glišić, SanjaArrigo, Patrizio
Alavantić, Dragan
Perović, Vladimir R.
Prljić, Jelena
Veljković, Nevena V.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism. Decrease of the LPL enzymatic activity leads to elevated triglycerides (TG) and reduced high-density lipoprotein (HDL-C levels), both risk factors for cardiovascular disease (CVD). Therefore, mutations, which decrease the LPL activity, may confer susceptibility to CVD. Here, the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of nucleotide and protein sequences, is applied for identification of evolutionary highly conserved information encoded by the primary structure of LPL. It was demonstrated that mutations, which alter the LPL enzymatic activity also alter this information. On the basis of this finding, an efficient an simple bioinformatics criterion for assessment of the pathogenic effect of LPL nonsynonymous single nucleotide substitution as a risk factor of CVD has been proposed.
Кључне речи:
LPL / informational spectrum method / mutational analysis / SNP / CVDИзвор:
Proteins: Structure Function and Bioinformatics, 2008, 70, 3, 855-862Финансирање / пројекти:
- Идентификација и карактеризација ћелијских кофактора ХИВ-а и њихова могућа примена у превентиви и терапији (RS-MESTD-MPN2006-2010-143001)
DOI: 10.1002/prot.21581
ISSN: 0887-3585
PubMed: 17803213
WoS: 000252836300022
Scopus: 2-s2.0-38549089000
Колекције
Институција/група
VinčaTY - JOUR AU - Glišić, Sanja AU - Arrigo, Patrizio AU - Alavantić, Dragan AU - Perović, Vladimir R. AU - Prljić, Jelena AU - Veljković, Nevena V. PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3356 AB - Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism. Decrease of the LPL enzymatic activity leads to elevated triglycerides (TG) and reduced high-density lipoprotein (HDL-C levels), both risk factors for cardiovascular disease (CVD). Therefore, mutations, which decrease the LPL activity, may confer susceptibility to CVD. Here, the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of nucleotide and protein sequences, is applied for identification of evolutionary highly conserved information encoded by the primary structure of LPL. It was demonstrated that mutations, which alter the LPL enzymatic activity also alter this information. On the basis of this finding, an efficient an simple bioinformatics criterion for assessment of the pathogenic effect of LPL nonsynonymous single nucleotide substitution as a risk factor of CVD has been proposed. T2 - Proteins: Structure Function and Bioinformatics T1 - Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease VL - 70 IS - 3 SP - 855 EP - 862 DO - 10.1002/prot.21581 ER -
@article{ author = "Glišić, Sanja and Arrigo, Patrizio and Alavantić, Dragan and Perović, Vladimir R. and Prljić, Jelena and Veljković, Nevena V.", year = "2008", abstract = "Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism. Decrease of the LPL enzymatic activity leads to elevated triglycerides (TG) and reduced high-density lipoprotein (HDL-C levels), both risk factors for cardiovascular disease (CVD). Therefore, mutations, which decrease the LPL activity, may confer susceptibility to CVD. Here, the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of nucleotide and protein sequences, is applied for identification of evolutionary highly conserved information encoded by the primary structure of LPL. It was demonstrated that mutations, which alter the LPL enzymatic activity also alter this information. On the basis of this finding, an efficient an simple bioinformatics criterion for assessment of the pathogenic effect of LPL nonsynonymous single nucleotide substitution as a risk factor of CVD has been proposed.", journal = "Proteins: Structure Function and Bioinformatics", title = "Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease", volume = "70", number = "3", pages = "855-862", doi = "10.1002/prot.21581" }
Glišić, S., Arrigo, P., Alavantić, D., Perović, V. R., Prljić, J.,& Veljković, N. V.. (2008). Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease. in Proteins: Structure Function and Bioinformatics, 70(3), 855-862. https://doi.org/10.1002/prot.21581
Glišić S, Arrigo P, Alavantić D, Perović VR, Prljić J, Veljković NV. Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease. in Proteins: Structure Function and Bioinformatics. 2008;70(3):855-862. doi:10.1002/prot.21581 .
Glišić, Sanja, Arrigo, Patrizio, Alavantić, Dragan, Perović, Vladimir R., Prljić, Jelena, Veljković, Nevena V., "Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease" in Proteins: Structure Function and Bioinformatics, 70, no. 3 (2008):855-862, https://doi.org/10.1002/prot.21581 . .