Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance
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Аутори
Svirtlih, NedaDelic, Dragan
Simonovic, Jasmina
Jevtović, Đorđe
Dokic, Ljubisa
Gvozdenovic, Eleonora
Boricic, Ivan
Terzić, Dragica
Pavic, Sladjana
Neskovic, Gorana
Zerjav, Sonja
Urban, Vladimir
Чланак у часопису
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Приказ свих података о документуАпстракт
AIM: To investigate the prevalence of hepatitis C virus (HCV) genotypes in Serbia and Montenegro and their influence on some clinical characteristics in patients with chronic HCV infection. METHODS: A total of 164 patients was investigated. Complete history route of infection, assessment of alcohol consumption, an abdominal ultrasound, standard biochemical tests and liver biopsy were done. Gene sequencing of 5 NTR type-specific PCR or commercial kits was performed for HCV genotyping and subtyping. The SPSS for Windows (version 10.0) was used for univariate regression analysis with further multivariate analysis. RESULTS: The genotypes 1, 2, 3, 4, 1b3a and 1b4 were present in 57.9%, 3.79/b, 23.2%, 6.7%, 6.7% and 1.8% of the patients, respectively. The genotype 1 (mainly the subtype 1b) was found to be independent of age in subjects older than 40 years, high viral load, more severe necro-inflammatory activity, advanced stage of fibrosis, and absence of intravenous drug abuse. The genotype... 3a was associated with intravenous drug abuse and the age below 40. Multivariate analysis demonstrated age over 40 and intravenous drug abuse as the positive predictive factors for the genotypes 1b and 3a, respectively. CONCLUSION: In Serbia and Montenegro, the genotypes 1b and 3a predominate in patients with chronic HCV infection. The subtype 1b is characteristic of older patients, while the genotype 3a is common in drug abusers. Association of the subtype lb with advanced liver disease, higher viral load and histological activity suggests earlier infection with this genotype and eventually its increased pathogenicity. (c) 2007 The WJG Press. All rights reserved.
Кључне речи:
hepatitis C virus / genotypes / prevalence / Serbia / MontenegroИзвор:
World Journal of Gastroenterology, 2007, 13, 3, 355-360
DOI: 10.3748/wjg.v13.i3.355
ISSN: 1007-9327
PubMed: 17230602
WoS: 000243613900004
Scopus: 2-s2.0-33846587958
Колекције
Институција/група
VinčaTY - JOUR AU - Svirtlih, Neda AU - Delic, Dragan AU - Simonovic, Jasmina AU - Jevtović, Đorđe AU - Dokic, Ljubisa AU - Gvozdenovic, Eleonora AU - Boricic, Ivan AU - Terzić, Dragica AU - Pavic, Sladjana AU - Neskovic, Gorana AU - Zerjav, Sonja AU - Urban, Vladimir PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3142 AB - AIM: To investigate the prevalence of hepatitis C virus (HCV) genotypes in Serbia and Montenegro and their influence on some clinical characteristics in patients with chronic HCV infection. METHODS: A total of 164 patients was investigated. Complete history route of infection, assessment of alcohol consumption, an abdominal ultrasound, standard biochemical tests and liver biopsy were done. Gene sequencing of 5 NTR type-specific PCR or commercial kits was performed for HCV genotyping and subtyping. The SPSS for Windows (version 10.0) was used for univariate regression analysis with further multivariate analysis. RESULTS: The genotypes 1, 2, 3, 4, 1b3a and 1b4 were present in 57.9%, 3.79/b, 23.2%, 6.7%, 6.7% and 1.8% of the patients, respectively. The genotype 1 (mainly the subtype 1b) was found to be independent of age in subjects older than 40 years, high viral load, more severe necro-inflammatory activity, advanced stage of fibrosis, and absence of intravenous drug abuse. The genotype 3a was associated with intravenous drug abuse and the age below 40. Multivariate analysis demonstrated age over 40 and intravenous drug abuse as the positive predictive factors for the genotypes 1b and 3a, respectively. CONCLUSION: In Serbia and Montenegro, the genotypes 1b and 3a predominate in patients with chronic HCV infection. The subtype 1b is characteristic of older patients, while the genotype 3a is common in drug abusers. Association of the subtype lb with advanced liver disease, higher viral load and histological activity suggests earlier infection with this genotype and eventually its increased pathogenicity. (c) 2007 The WJG Press. All rights reserved. T2 - World Journal of Gastroenterology T1 - Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance VL - 13 IS - 3 SP - 355 EP - 360 DO - 10.3748/wjg.v13.i3.355 ER -
@article{ author = "Svirtlih, Neda and Delic, Dragan and Simonovic, Jasmina and Jevtović, Đorđe and Dokic, Ljubisa and Gvozdenovic, Eleonora and Boricic, Ivan and Terzić, Dragica and Pavic, Sladjana and Neskovic, Gorana and Zerjav, Sonja and Urban, Vladimir", year = "2007", abstract = "AIM: To investigate the prevalence of hepatitis C virus (HCV) genotypes in Serbia and Montenegro and their influence on some clinical characteristics in patients with chronic HCV infection. METHODS: A total of 164 patients was investigated. Complete history route of infection, assessment of alcohol consumption, an abdominal ultrasound, standard biochemical tests and liver biopsy were done. Gene sequencing of 5 NTR type-specific PCR or commercial kits was performed for HCV genotyping and subtyping. The SPSS for Windows (version 10.0) was used for univariate regression analysis with further multivariate analysis. RESULTS: The genotypes 1, 2, 3, 4, 1b3a and 1b4 were present in 57.9%, 3.79/b, 23.2%, 6.7%, 6.7% and 1.8% of the patients, respectively. The genotype 1 (mainly the subtype 1b) was found to be independent of age in subjects older than 40 years, high viral load, more severe necro-inflammatory activity, advanced stage of fibrosis, and absence of intravenous drug abuse. The genotype 3a was associated with intravenous drug abuse and the age below 40. Multivariate analysis demonstrated age over 40 and intravenous drug abuse as the positive predictive factors for the genotypes 1b and 3a, respectively. CONCLUSION: In Serbia and Montenegro, the genotypes 1b and 3a predominate in patients with chronic HCV infection. The subtype 1b is characteristic of older patients, while the genotype 3a is common in drug abusers. Association of the subtype lb with advanced liver disease, higher viral load and histological activity suggests earlier infection with this genotype and eventually its increased pathogenicity. (c) 2007 The WJG Press. All rights reserved.", journal = "World Journal of Gastroenterology", title = "Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance", volume = "13", number = "3", pages = "355-360", doi = "10.3748/wjg.v13.i3.355" }
Svirtlih, N., Delic, D., Simonovic, J., Jevtović, Đ., Dokic, L., Gvozdenovic, E., Boricic, I., Terzić, D., Pavic, S., Neskovic, G., Zerjav, S.,& Urban, V.. (2007). Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance. in World Journal of Gastroenterology, 13(3), 355-360. https://doi.org/10.3748/wjg.v13.i3.355
Svirtlih N, Delic D, Simonovic J, Jevtović Đ, Dokic L, Gvozdenovic E, Boricic I, Terzić D, Pavic S, Neskovic G, Zerjav S, Urban V. Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance. in World Journal of Gastroenterology. 2007;13(3):355-360. doi:10.3748/wjg.v13.i3.355 .
Svirtlih, Neda, Delic, Dragan, Simonovic, Jasmina, Jevtović, Đorđe, Dokic, Ljubisa, Gvozdenovic, Eleonora, Boricic, Ivan, Terzić, Dragica, Pavic, Sladjana, Neskovic, Gorana, Zerjav, Sonja, Urban, Vladimir, "Hepatitis C virus genotypes in Serbia and Montenegro: The prevalence and clinical significance" in World Journal of Gastroenterology, 13, no. 3 (2007):355-360, https://doi.org/10.3748/wjg.v13.i3.355 . .