Time-Related Sex Diffrences in Cerebral Hypoperfusion-Induced Brain Injury
2014
Аутори
Stanojlović, Miloš R.Guševac, Ivana
Grković, Ivana
Mitrović, Nataša Lj.
Horvat, Anica
Drakulić, Dunja R.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Although the model of cerebral hypoperfusion in rats has been a matter of many investigations over the years, the exact intracellular and biochemical mechanisms that lead to neuron loss and memory decline have not been clearly identified. In the current study, we examined whether cerebral hypoperfusion causes changes in hippocampal protein expression of apoptotic markers in the synaptosomal fraction and neurodegeneration in a time-dependent and sex-specific manner. Adult male and female Wistar rats were divided into two main groups, controls that underwent sham operation, and animals subjected to permanent bilateral occlusion of common carotid arteries. Both male and female rats were killed 3, 7 or 90 days following the insult. The obtained results indicate that the peak of processes that lead to apoptosis occured on postoperative day 7 and that they were more prominent in males, indicating that neuroprotective effects of certain substances (planned for future experiments), should be t...ested at this time point.
Кључне речи:
cerebral hypoperfusion / apoptosis / gender / hippocampusИзвор:
Archives of Biological Sciences, 2014, 66, 4, 1673-1680Финансирање / пројекти:
- Молекуларни механизми патофизиолошких промена у ћелијама централног нервног система и периферног ткива код сисара (RS-MESTD-Basic Research (BR or ON)-173044)
- Ћелијска и молекулска основа неуроинфламације: потенцијала циљна места за транслациону медицину и терапију (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41014)
DOI: 10.2298/ABS1404673S
ISSN: 0354-4664; 1821-4339
WoS: 000346477900045
Scopus: 2-s2.0-84921652306
Колекције
Институција/група
VinčaTY - JOUR AU - Stanojlović, Miloš R. AU - Guševac, Ivana AU - Grković, Ivana AU - Mitrović, Nataša Lj. AU - Horvat, Anica AU - Drakulić, Dunja R. PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/301 AB - Although the model of cerebral hypoperfusion in rats has been a matter of many investigations over the years, the exact intracellular and biochemical mechanisms that lead to neuron loss and memory decline have not been clearly identified. In the current study, we examined whether cerebral hypoperfusion causes changes in hippocampal protein expression of apoptotic markers in the synaptosomal fraction and neurodegeneration in a time-dependent and sex-specific manner. Adult male and female Wistar rats were divided into two main groups, controls that underwent sham operation, and animals subjected to permanent bilateral occlusion of common carotid arteries. Both male and female rats were killed 3, 7 or 90 days following the insult. The obtained results indicate that the peak of processes that lead to apoptosis occured on postoperative day 7 and that they were more prominent in males, indicating that neuroprotective effects of certain substances (planned for future experiments), should be tested at this time point. T2 - Archives of Biological Sciences T1 - Time-Related Sex Diffrences in Cerebral Hypoperfusion-Induced Brain Injury VL - 66 IS - 4 SP - 1673 EP - 1680 DO - 10.2298/ABS1404673S ER -
@article{ author = "Stanojlović, Miloš R. and Guševac, Ivana and Grković, Ivana and Mitrović, Nataša Lj. and Horvat, Anica and Drakulić, Dunja R.", year = "2014", abstract = "Although the model of cerebral hypoperfusion in rats has been a matter of many investigations over the years, the exact intracellular and biochemical mechanisms that lead to neuron loss and memory decline have not been clearly identified. In the current study, we examined whether cerebral hypoperfusion causes changes in hippocampal protein expression of apoptotic markers in the synaptosomal fraction and neurodegeneration in a time-dependent and sex-specific manner. Adult male and female Wistar rats were divided into two main groups, controls that underwent sham operation, and animals subjected to permanent bilateral occlusion of common carotid arteries. Both male and female rats were killed 3, 7 or 90 days following the insult. The obtained results indicate that the peak of processes that lead to apoptosis occured on postoperative day 7 and that they were more prominent in males, indicating that neuroprotective effects of certain substances (planned for future experiments), should be tested at this time point.", journal = "Archives of Biological Sciences", title = "Time-Related Sex Diffrences in Cerebral Hypoperfusion-Induced Brain Injury", volume = "66", number = "4", pages = "1673-1680", doi = "10.2298/ABS1404673S" }
Stanojlović, M. R., Guševac, I., Grković, I., Mitrović, N. Lj., Horvat, A.,& Drakulić, D. R.. (2014). Time-Related Sex Diffrences in Cerebral Hypoperfusion-Induced Brain Injury. in Archives of Biological Sciences, 66(4), 1673-1680. https://doi.org/10.2298/ABS1404673S
Stanojlović MR, Guševac I, Grković I, Mitrović NL, Horvat A, Drakulić DR. Time-Related Sex Diffrences in Cerebral Hypoperfusion-Induced Brain Injury. in Archives of Biological Sciences. 2014;66(4):1673-1680. doi:10.2298/ABS1404673S .
Stanojlović, Miloš R., Guševac, Ivana, Grković, Ivana, Mitrović, Nataša Lj., Horvat, Anica, Drakulić, Dunja R., "Time-Related Sex Diffrences in Cerebral Hypoperfusion-Induced Brain Injury" in Archives of Biological Sciences, 66, no. 4 (2014):1673-1680, https://doi.org/10.2298/ABS1404673S . .