Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit
Само за регистроване кориснике
2017
Аутори
Pinkney, T.Gvozdenović, M.
Jovanović, Dragana J.
Lausevic, Z.
Cvetković, D.
Maravic, M.
Milovanović, Branislav
Stojakovic, N.
Tripkovic, I.
Mihajlovic, D.
Nestorović, M.
Pecic, V.
Petrović, D.
Stanojevic, G.
Barisic, G.
Dimitrijevic, I.
Krivokapic, Z.
Markovic, V.
Popović, Milan
Aleksić, A.
Dabic, D.
Kostic, I.
Milojkovic, A.
Perunicic, V.
Lukić, Dejan
Petrović, T.
Radovanovic, D.
Radovanovic, Z.
Cuk, V. M.
Cuk, V. V.
Kenic, M.
Kovacevic, B.
Krdzic, I.
(ukupan broj autora: 1112)
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Aim The anastomosis technique used following right-sided colonic resection is widely variable and may affect patient outcome. This study aimed to assess the association between leak and anastomosis technique (stapled vs handsewn). Method This was a prospective, multicentre, international audit including patients undergoing elective or emergency right hemicolectomy or ileo-caecal resection operations over a 2-month period in early 2015. The primary outcome measure was the presence of anastomotic leak within 30 days of surgery, determined using a prespecified definition. Mixed effects logistic regression models were used to assess the association between leak and anastomosis method, adjusting for patient, disease and operative cofactors, with centre included as a random-effect variable. Results This study included 3208 patients, of whom 78.4% (n = 2515) underwent surgery for malignancy and 11.7% (n = 375) underwent surgery for Crohns disease. An anastomosis was performed in 94.8% (n = 30...41) of patients, which was handsewn in 38.9% (n = 1183) and stapled in 61.1% (n = 1858). Patients undergoing hand-sewn anastomosis were more likely to be emergency admissions (20.5% handsewn vs 12.9% stapled) and to undergo open surgery (54.7% handsewn vs 36.6% stapled). The overall anastomotic leak rate was 8.1% (245/3041), which was similar following handsewn (7.4%) and stapled (8.5%) techniques (P = 0.3). After adjustment for cofactors, the odds of a leak were higher for stapled anastomosis (adjusted OR = 1.43; 95% CI: 1.04-1.95; P = 0.03). Conclusion Despite being used in lower-risk patients, stapled anastomosis was associated with an increased anastomotic leak rate in this observational study. Further research is needed to define patient groups in whom a stapled anastomosis is safe.
Кључне речи:
Anastomotic leak / colorectal cancer / Crohns disease / epidemiology / internationalИзвор:
Colorectal Disease, 2017, 19, 8, O296-O311
DOI: 10.1111/codi.13646
ISSN: 1462-8910; 1463-1318
WoS: 000406961000003
Scopus: 2-s2.0-85026746396
Институција/група
VinčaTY - JOUR AU - Pinkney, T. AU - Gvozdenović, M. AU - Jovanović, Dragana J. AU - Lausevic, Z. AU - Cvetković, D. AU - Maravic, M. AU - Milovanović, Branislav AU - Stojakovic, N. AU - Tripkovic, I. AU - Mihajlovic, D. AU - Nestorović, M. AU - Pecic, V. AU - Petrović, D. AU - Stanojevic, G. AU - Barisic, G. AU - Dimitrijevic, I. AU - Krivokapic, Z. AU - Markovic, V. AU - Popović, Milan AU - Aleksić, A. AU - Dabic, D. AU - Kostic, I. AU - Milojkovic, A. AU - Perunicic, V. AU - Lukić, Dejan AU - Petrović, T. AU - Radovanovic, D. AU - Radovanovic, Z. AU - Cuk, V. M. AU - Cuk, V. V. AU - Kenic, M. AU - Kovacevic, B. AU - Krdzic, I. PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1667 AB - Aim The anastomosis technique used following right-sided colonic resection is widely variable and may affect patient outcome. This study aimed to assess the association between leak and anastomosis technique (stapled vs handsewn). Method This was a prospective, multicentre, international audit including patients undergoing elective or emergency right hemicolectomy or ileo-caecal resection operations over a 2-month period in early 2015. The primary outcome measure was the presence of anastomotic leak within 30 days of surgery, determined using a prespecified definition. Mixed effects logistic regression models were used to assess the association between leak and anastomosis method, adjusting for patient, disease and operative cofactors, with centre included as a random-effect variable. Results This study included 3208 patients, of whom 78.4% (n = 2515) underwent surgery for malignancy and 11.7% (n = 375) underwent surgery for Crohns disease. An anastomosis was performed in 94.8% (n = 3041) of patients, which was handsewn in 38.9% (n = 1183) and stapled in 61.1% (n = 1858). Patients undergoing hand-sewn anastomosis were more likely to be emergency admissions (20.5% handsewn vs 12.9% stapled) and to undergo open surgery (54.7% handsewn vs 36.6% stapled). The overall anastomotic leak rate was 8.1% (245/3041), which was similar following handsewn (7.4%) and stapled (8.5%) techniques (P = 0.3). After adjustment for cofactors, the odds of a leak were higher for stapled anastomosis (adjusted OR = 1.43; 95% CI: 1.04-1.95; P = 0.03). Conclusion Despite being used in lower-risk patients, stapled anastomosis was associated with an increased anastomotic leak rate in this observational study. Further research is needed to define patient groups in whom a stapled anastomosis is safe. T2 - Colorectal Disease T1 - Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit VL - 19 IS - 8 SP - O296 EP - O311 DO - 10.1111/codi.13646 ER -
@article{ author = "Pinkney, T. and Gvozdenović, M. and Jovanović, Dragana J. and Lausevic, Z. and Cvetković, D. and Maravic, M. and Milovanović, Branislav and Stojakovic, N. and Tripkovic, I. and Mihajlovic, D. and Nestorović, M. and Pecic, V. and Petrović, D. and Stanojevic, G. and Barisic, G. and Dimitrijevic, I. and Krivokapic, Z. and Markovic, V. and Popović, Milan and Aleksić, A. and Dabic, D. and Kostic, I. and Milojkovic, A. and Perunicic, V. and Lukić, Dejan and Petrović, T. and Radovanovic, D. and Radovanovic, Z. and Cuk, V. M. and Cuk, V. V. and Kenic, M. and Kovacevic, B. and Krdzic, I.", year = "2017", abstract = "Aim The anastomosis technique used following right-sided colonic resection is widely variable and may affect patient outcome. This study aimed to assess the association between leak and anastomosis technique (stapled vs handsewn). Method This was a prospective, multicentre, international audit including patients undergoing elective or emergency right hemicolectomy or ileo-caecal resection operations over a 2-month period in early 2015. The primary outcome measure was the presence of anastomotic leak within 30 days of surgery, determined using a prespecified definition. Mixed effects logistic regression models were used to assess the association between leak and anastomosis method, adjusting for patient, disease and operative cofactors, with centre included as a random-effect variable. Results This study included 3208 patients, of whom 78.4% (n = 2515) underwent surgery for malignancy and 11.7% (n = 375) underwent surgery for Crohns disease. An anastomosis was performed in 94.8% (n = 3041) of patients, which was handsewn in 38.9% (n = 1183) and stapled in 61.1% (n = 1858). Patients undergoing hand-sewn anastomosis were more likely to be emergency admissions (20.5% handsewn vs 12.9% stapled) and to undergo open surgery (54.7% handsewn vs 36.6% stapled). The overall anastomotic leak rate was 8.1% (245/3041), which was similar following handsewn (7.4%) and stapled (8.5%) techniques (P = 0.3). After adjustment for cofactors, the odds of a leak were higher for stapled anastomosis (adjusted OR = 1.43; 95% CI: 1.04-1.95; P = 0.03). Conclusion Despite being used in lower-risk patients, stapled anastomosis was associated with an increased anastomotic leak rate in this observational study. Further research is needed to define patient groups in whom a stapled anastomosis is safe.", journal = "Colorectal Disease", title = "Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit", volume = "19", number = "8", pages = "O296-O311", doi = "10.1111/codi.13646" }
Pinkney, T., Gvozdenović, M., Jovanović, D. J., Lausevic, Z., Cvetković, D., Maravic, M., Milovanović, B., Stojakovic, N., Tripkovic, I., Mihajlovic, D., Nestorović, M., Pecic, V., Petrović, D., Stanojevic, G., Barisic, G., Dimitrijevic, I., Krivokapic, Z., Markovic, V., Popović, M., Aleksić, A., Dabic, D., Kostic, I., Milojkovic, A., Perunicic, V., Lukić, D., Petrović, T., Radovanovic, D., Radovanovic, Z., Cuk, V. M., Cuk, V. V., Kenic, M., Kovacevic, B.,& Krdzic, I.. (2017). Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit. in Colorectal Disease, 19(8), O296-O311. https://doi.org/10.1111/codi.13646
Pinkney T, Gvozdenović M, Jovanović DJ, Lausevic Z, Cvetković D, Maravic M, Milovanović B, Stojakovic N, Tripkovic I, Mihajlovic D, Nestorović M, Pecic V, Petrović D, Stanojevic G, Barisic G, Dimitrijevic I, Krivokapic Z, Markovic V, Popović M, Aleksić A, Dabic D, Kostic I, Milojkovic A, Perunicic V, Lukić D, Petrović T, Radovanovic D, Radovanovic Z, Cuk VM, Cuk VV, Kenic M, Kovacevic B, Krdzic I. Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit. in Colorectal Disease. 2017;19(8):O296-O311. doi:10.1111/codi.13646 .
Pinkney, T., Gvozdenović, M., Jovanović, Dragana J., Lausevic, Z., Cvetković, D., Maravic, M., Milovanović, Branislav, Stojakovic, N., Tripkovic, I., Mihajlovic, D., Nestorović, M., Pecic, V., Petrović, D., Stanojevic, G., Barisic, G., Dimitrijevic, I., Krivokapic, Z., Markovic, V., Popović, Milan, Aleksić, A., Dabic, D., Kostic, I., Milojkovic, A., Perunicic, V., Lukić, Dejan, Petrović, T., Radovanovic, D., Radovanovic, Z., Cuk, V. M., Cuk, V. V., Kenic, M., Kovacevic, B., Krdzic, I., "Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection: an international snapshot audit" in Colorectal Disease, 19, no. 8 (2017):O296-O311, https://doi.org/10.1111/codi.13646 . .