Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes
2017
Аутори
Rakić-Kostić, Tijana M.Bogojeski, Jovana V.
Popović, Iva A.
Nešić, Maja D.
Rajčić, Boris
Nišavić, Marija
Petković, Marijana
Veličković, Suzana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This paper presents optimization of matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer (MS) instrumental parameters for the analysis of chloro(2,2 , 2 -terpyridine) palladium(II) chloride dihydrate complex applying design of experiments methodology (DoE). This complex is of interest for potential use in the cancer therapy. DoE methodology was proved to succeed in optimization of many complex analytical problems. However, it has been poorly used for MALDI-TOF-MS optimization up to now. The theoretical mathematical relationships which explain the influence of important experimental factors (laser energy, grid voltage and number of laser shots) on the selected responses (signal to noise - S/N ratio and the resolution - R of the leading peak) is established. The optimal instrumental settings providing maximal S/N and R are identified and experimentally verified.
Кључне речи:
MALDI-TOF-MS / design of experiments (DoE) / optimization / metallo-drugsИзвор:
Hemijska industrija, 2017, 71, 4, 281-288Финансирање / пројекти:
- Моделовање различитих хроматографских система са хемометријским приступом у фармацеутској анализи (RS-MESTD-Basic Research (BR or ON)-172052)
- Испитивање механизма реакција комплекса јона прелазних метала са биолошки значајним молекулима (RS-MESTD-Basic Research (BR or ON)-172011)
DOI: 10.2298/HEMIND160614038R
ISSN: 0367-598X; 2217-7426
WoS: 000413180100001
Scopus: 2-s2.0-85030247844
Колекције
Институција/група
VinčaTY - JOUR AU - Rakić-Kostić, Tijana M. AU - Bogojeski, Jovana V. AU - Popović, Iva A. AU - Nešić, Maja D. AU - Rajčić, Boris AU - Nišavić, Marija AU - Petković, Marijana AU - Veličković, Suzana PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1362 AB - This paper presents optimization of matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer (MS) instrumental parameters for the analysis of chloro(2,2 , 2 -terpyridine) palladium(II) chloride dihydrate complex applying design of experiments methodology (DoE). This complex is of interest for potential use in the cancer therapy. DoE methodology was proved to succeed in optimization of many complex analytical problems. However, it has been poorly used for MALDI-TOF-MS optimization up to now. The theoretical mathematical relationships which explain the influence of important experimental factors (laser energy, grid voltage and number of laser shots) on the selected responses (signal to noise - S/N ratio and the resolution - R of the leading peak) is established. The optimal instrumental settings providing maximal S/N and R are identified and experimentally verified. T2 - Hemijska industrija T1 - Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes VL - 71 IS - 4 SP - 281 EP - 288 DO - 10.2298/HEMIND160614038R ER -
@article{ author = "Rakić-Kostić, Tijana M. and Bogojeski, Jovana V. and Popović, Iva A. and Nešić, Maja D. and Rajčić, Boris and Nišavić, Marija and Petković, Marijana and Veličković, Suzana", year = "2017", abstract = "This paper presents optimization of matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer (MS) instrumental parameters for the analysis of chloro(2,2 , 2 -terpyridine) palladium(II) chloride dihydrate complex applying design of experiments methodology (DoE). This complex is of interest for potential use in the cancer therapy. DoE methodology was proved to succeed in optimization of many complex analytical problems. However, it has been poorly used for MALDI-TOF-MS optimization up to now. The theoretical mathematical relationships which explain the influence of important experimental factors (laser energy, grid voltage and number of laser shots) on the selected responses (signal to noise - S/N ratio and the resolution - R of the leading peak) is established. The optimal instrumental settings providing maximal S/N and R are identified and experimentally verified.", journal = "Hemijska industrija", title = "Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes", volume = "71", number = "4", pages = "281-288", doi = "10.2298/HEMIND160614038R" }
Rakić-Kostić, T. M., Bogojeski, J. V., Popović, I. A., Nešić, M. D., Rajčić, B., Nišavić, M., Petković, M.,& Veličković, S.. (2017). Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes. in Hemijska industrija, 71(4), 281-288. https://doi.org/10.2298/HEMIND160614038R
Rakić-Kostić TM, Bogojeski JV, Popović IA, Nešić MD, Rajčić B, Nišavić M, Petković M, Veličković S. Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes. in Hemijska industrija. 2017;71(4):281-288. doi:10.2298/HEMIND160614038R .
Rakić-Kostić, Tijana M., Bogojeski, Jovana V., Popović, Iva A., Nešić, Maja D., Rajčić, Boris, Nišavić, Marija, Petković, Marijana, Veličković, Suzana, "Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes" in Hemijska industrija, 71, no. 4 (2017):281-288, https://doi.org/10.2298/HEMIND160614038R . .