Inhibition by blueberries (bilberries) and extract from milk thistle of rat forestomach hyperplasia induced by oral smokeless tobacco (Swedish snus)
Само за регистроване кориснике
2016
Аутори
Nilsson, RobertMićić, Mileva
Filipović, Jelena G.
Valenta-Šobot, Ana
Drakulić, Dunja R.
Stanojlović, Miloš R.
Joksić, Gordana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to identify palatable additives which have a significant protective action against soft tissue changes in the oral cavity caused by Swedish smokeless tobacco (snus), and that satisfy existing legal requirements. Although the cancer risk from snus is extremely low, long term use may result in highly undesirable keratotic lesions and associated epithelial abnormalities in the oral cavity. The rat forestomach, which is vulnerable to the irritative action of non-genotoxic compounds like butylated hydroxyanisole, propionic acid as well as snus, was chosen as an experimental model. Studied toxicological endpoints included histopathology and cellular proliferation based on DNA incorporation of bromodeoxyuridine. After 6 weeks exposure, blueberries (bilberries) and an extract from the common milk thistle were found to exert a highly significant inhibition of cell proliferation induced by snus in the rat forestomach epithelium, indicating a potential protection with re...spect soft tissue changes in the human oral cavity. (C) 2016 Elsevier Inc. All rights reserved.
Кључне речи:
Smokeless tobacco / Snus / Forestomach / Hyperplasia / Bromodeoxyuridine / Phytoprotection / Blueberries / Silymarin / Milk thistleИзвор:
Regulatory Toxicology and Pharmacology, 2016, 76, 94-101Издавач:
- Elsevier
Финансирање / пројекти:
- Swedish Match AB
DOI: 10.1016/j.yrtph.2016.01.017
ISSN: 0273-2300; 1096-0295
PubMed: 26828024
WoS: 000375514200012
Scopus: 2-s2.0-84956698299
Колекције
Институција/група
VinčaTY - JOUR AU - Nilsson, Robert AU - Mićić, Mileva AU - Filipović, Jelena G. AU - Valenta-Šobot, Ana AU - Drakulić, Dunja R. AU - Stanojlović, Miloš R. AU - Joksić, Gordana PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1058 AB - The aim of this study was to identify palatable additives which have a significant protective action against soft tissue changes in the oral cavity caused by Swedish smokeless tobacco (snus), and that satisfy existing legal requirements. Although the cancer risk from snus is extremely low, long term use may result in highly undesirable keratotic lesions and associated epithelial abnormalities in the oral cavity. The rat forestomach, which is vulnerable to the irritative action of non-genotoxic compounds like butylated hydroxyanisole, propionic acid as well as snus, was chosen as an experimental model. Studied toxicological endpoints included histopathology and cellular proliferation based on DNA incorporation of bromodeoxyuridine. After 6 weeks exposure, blueberries (bilberries) and an extract from the common milk thistle were found to exert a highly significant inhibition of cell proliferation induced by snus in the rat forestomach epithelium, indicating a potential protection with respect soft tissue changes in the human oral cavity. (C) 2016 Elsevier Inc. All rights reserved. PB - Elsevier T2 - Regulatory Toxicology and Pharmacology T1 - Inhibition by blueberries (bilberries) and extract from milk thistle of rat forestomach hyperplasia induced by oral smokeless tobacco (Swedish snus) VL - 76 SP - 94 EP - 101 DO - 10.1016/j.yrtph.2016.01.017 ER -
@article{ author = "Nilsson, Robert and Mićić, Mileva and Filipović, Jelena G. and Valenta-Šobot, Ana and Drakulić, Dunja R. and Stanojlović, Miloš R. and Joksić, Gordana", year = "2016", abstract = "The aim of this study was to identify palatable additives which have a significant protective action against soft tissue changes in the oral cavity caused by Swedish smokeless tobacco (snus), and that satisfy existing legal requirements. Although the cancer risk from snus is extremely low, long term use may result in highly undesirable keratotic lesions and associated epithelial abnormalities in the oral cavity. The rat forestomach, which is vulnerable to the irritative action of non-genotoxic compounds like butylated hydroxyanisole, propionic acid as well as snus, was chosen as an experimental model. Studied toxicological endpoints included histopathology and cellular proliferation based on DNA incorporation of bromodeoxyuridine. After 6 weeks exposure, blueberries (bilberries) and an extract from the common milk thistle were found to exert a highly significant inhibition of cell proliferation induced by snus in the rat forestomach epithelium, indicating a potential protection with respect soft tissue changes in the human oral cavity. (C) 2016 Elsevier Inc. All rights reserved.", publisher = "Elsevier", journal = "Regulatory Toxicology and Pharmacology", title = "Inhibition by blueberries (bilberries) and extract from milk thistle of rat forestomach hyperplasia induced by oral smokeless tobacco (Swedish snus)", volume = "76", pages = "94-101", doi = "10.1016/j.yrtph.2016.01.017" }
Nilsson, R., Mićić, M., Filipović, J. G., Valenta-Šobot, A., Drakulić, D. R., Stanojlović, M. R.,& Joksić, G.. (2016). Inhibition by blueberries (bilberries) and extract from milk thistle of rat forestomach hyperplasia induced by oral smokeless tobacco (Swedish snus). in Regulatory Toxicology and Pharmacology Elsevier., 76, 94-101. https://doi.org/10.1016/j.yrtph.2016.01.017
Nilsson R, Mićić M, Filipović JG, Valenta-Šobot A, Drakulić DR, Stanojlović MR, Joksić G. Inhibition by blueberries (bilberries) and extract from milk thistle of rat forestomach hyperplasia induced by oral smokeless tobacco (Swedish snus). in Regulatory Toxicology and Pharmacology. 2016;76:94-101. doi:10.1016/j.yrtph.2016.01.017 .
Nilsson, Robert, Mićić, Mileva, Filipović, Jelena G., Valenta-Šobot, Ana, Drakulić, Dunja R., Stanojlović, Miloš R., Joksić, Gordana, "Inhibition by blueberries (bilberries) and extract from milk thistle of rat forestomach hyperplasia induced by oral smokeless tobacco (Swedish snus)" in Regulatory Toxicology and Pharmacology, 76 (2016):94-101, https://doi.org/10.1016/j.yrtph.2016.01.017 . .